Department of Neurosurgery, Xinqiao Hospital, Army Medical University, Chongqing, China.
Front Immunol. 2021 Apr 27;12:667454. doi: 10.3389/fimmu.2021.667454. eCollection 2021.
Toll-like receptor 3 (TLR3) is an important member of the TLR family, which is an important group of pathogen-associated molecular patterns. TLR3 can recognize double-stranded RNA and induce activation of NF-κB and the production of type I interferons. In addition to its immune-associated role, TLR3 has also been detected in some tumors. However TLR3 can play protumor or antitumor roles in different tumors or cell lines. Here, we review the basic signaling associated with TLR3 and the pro- or antitumor roles of TLR3 in different types of tumors and discuss the possible reasons for the opposing roles of TLR3 in tumors.
Toll 样受体 3（TLR3）是 TLR 家族的重要成员，TLR 家族是病原体相关分子模式的重要组成部分。TLR3 可以识别双链 RNA，并诱导 NF-κB 的激活和 I 型干扰素的产生。除了其与免疫相关的作用外，TLR3 也在一些肿瘤中被检测到。然而，TLR3 在不同的肿瘤或细胞系中可能发挥促肿瘤或抗肿瘤的作用。在这里，我们回顾了与 TLR3 相关的基本信号转导以及 TLR3 在不同类型肿瘤中的促肿瘤或抗肿瘤作用，并讨论了 TLR3 在肿瘤中发挥相反作用的可能原因。
