Ma Jian-Chun, Zhang Hao-Liang, Huang Hui-Ping, Ma Zao-Liang, Chen Su-Fang, Qiu Zhi-Kun, Chen Ji-Sheng
Pharmaceutical Department of The First Affiliated Hospital of Guangdong Pharmaceutical University, Clinical Pharmacy Department of Guangdong Pharmaceutical University, Guangzhou, Guangdong 510080, P.R. China.
Exp Ther Med. 2021 Jul;22(1):677. doi: 10.3892/etm.2021.10109. Epub 2021 Apr 25.
Depression is a significant public health issue and its neuropathogenesis is associated with the dysfunction of progesterone and allopregnanolone biosynthesis. Z-ligustilide (LIG), one of the main components of the herb (AS), is reported to have antidepressant activities. The present study aimed to evaluate the antidepressant-like effects of LIG via behavioral tests and to measure the levels of progesterone and allopregnanolone in the prefrontal cortex and hippocampus. The results demonstrated that LIG (20 and 40 mg/kg) exerted antidepressant-like effects, confirmed by increased mobility, locomotion, rearing frequency and preference to sucrose. Furthermore, the levels of progesterone and allopregnanolone in the prefrontal cortex and hippocampus were markedly increased following treatment with LIG (20 and 40 mg/kg), indicating that both neurosteroids could serve a significant role in the antidepressant-like effects of LIG.
抑郁症是一个重大的公共卫生问题，其神经发病机制与孕酮和别孕烷醇酮生物合成功能障碍有关。Z-藁本内酯（LIG）是草药（AS）的主要成分之一，据报道具有抗抑郁活性。本研究旨在通过行为测试评估LIG的抗抑郁样作用，并测量前额叶皮质和海马体中孕酮和别孕烷醇酮的水平。结果表明，LIG（20和40mg/kg）发挥了抗抑郁样作用，表现为活动能力、运动能力、竖毛频率增加以及对蔗糖的偏好增加，从而得到证实。此外，用LIG（20和40mg/kg）处理后，前额叶皮质和海马体中孕酮和别孕烷醇酮的水平显著升高，表明这两种神经甾体在LIG的抗抑郁样作用中可能起重要作用。
