Fariello R G, Ferraro T N, Golden G T, DeMattei M
Department of Neurological Sciences, Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL.
Life Sci. 1988;43(3):289-92. doi: 10.1016/0024-3205(88)90319-0.
Amino acid and reduced glutathione (GSH) levels in substantia nigra (SN) as well as striatal monoamine levels were measured in acetyl-L-carnitine (ALCar) treated and control Swiss-Webster mice. ALCar, L carnitine, or saline were administered i.p. to mice for 5 days and mice were decapitated 24 hours following the last injection. Substantia nigra and striata were isolated within 2.5 and 3 min., respectively, and frozen immediately on dry ice. A significant dose-dependent increase of nigral GABA was observed following ALCar treatment; GABA levels were also increased by administration of carnitine. Nigral GSH levels were also increased. Striatal levels of dopamine and metabolites were not significantly affected by ALCar or carnitine. These results, suggest that ALCar may be useful in treating symptoms of neuronal dysfunction related to accumulation of metabolic waste.
在接受乙酰左旋肉碱（ALCar）治疗的和对照的瑞士 Webster 小鼠中，测量了黑质（SN）中的氨基酸和还原型谷胱甘肽（GSH）水平以及纹状体单胺水平。将 ALCar、左旋肉碱或生理盐水腹腔注射给小鼠，持续 5 天，并在最后一次注射后 24 小时将小鼠断头。分别在 2.5 分钟和 3 分钟内分离出黑质和纹状体，并立即在干冰上冷冻。在 ALCar 治疗后观察到黑质 GABA 有显著的剂量依赖性增加；左旋肉碱给药也使 GABA 水平升高。黑质 GSH 水平也升高。ALCar 或左旋肉碱对纹状体多巴胺及其代谢产物水平没有显著影响。这些结果表明，ALCar 可能有助于治疗与代谢废物积累相关的神经元功能障碍症状。
