对氧化震颤素作用于毒扁豆碱耐受大鼠的程序控制行为的耐受性。

Tolerance to oxotremorine's effects on schedule-controlled behavior in physostigmine-tolerant rats.

作者信息

Genovese R F, Elsmore T F, King L R

机构信息

Department of Medical Neurosciences, Walter Reed Army Institute of Research, Washington D.C. 20307-5100.

出版信息

Life Sci. 1988;43(7):571-6. doi: 10.1016/0024-3205(88)90060-4.

DOI:10.1016/0024-3205(88)90060-4

PMID:3398709

Abstract

Tolerance to the effects of physostigmine and oxotremorine in rats was evaluated using a multiple fixed-ratio 10, extinction schedule of food presentation. Physostigmine was administered either once daily or three times daily for 18 consecutive days. Tolerance to physostigmine's response decreasing effects was observed under both administration regimens. Cumulative dose-effect functions for oxotremorine (0.0056-0.562 mg/kg) were determined before and after chronic physostigmine administration. Oxotremorine's potency to produce response rate suppression decreased in rats receiving physostigmine three times daily but did not substantially change in rats receiving single daily injections. These results demonstrate that the dose or duration of action of physostigmine can determine whether tolerance to physostigmine's effects is accompanied by cross-tolerance to oxotremorine's effects.

摘要

采用多次固定比率10的食物呈现消退程序，评估大鼠对毒扁豆碱和氧化震颤素作用的耐受性。连续18天每天给予毒扁豆碱一次或三次。在两种给药方案下均观察到对毒扁豆碱反应减弱作用的耐受性。在慢性给予毒扁豆碱前后，测定了氧化震颤素（0.0056 - 0.562 mg/kg）的累积剂量效应函数。每天接受三次毒扁豆碱注射的大鼠中，氧化震颤素产生反应率抑制的效力降低，但每天接受单次注射的大鼠中其效力没有显著变化。这些结果表明，毒扁豆碱的剂量或作用持续时间可以决定对毒扁豆碱作用的耐受性是否伴随着对氧化震颤素作用的交叉耐受性。