Ingber A, Alcalay J, Sandbank M
Department of Dermatology, Beilinson Medical Center, Petah Tiqva, Israel.
Med Hypotheses. 1988 May;26(1):11-2. doi: 10.1016/0306-9877(88)90105-3.
We have recently demonstrated that in pruritic urticarial papules and plaques of pregnancy (PUPPP) there are multiple dermal fibroblasts with no deposition of mucin. We suggest that in the dermis of patients with PUPPP there is a deposition of a substance that induces fibroblasts proliferation. We assume that this substance (marked as F-substance) is a product of the placenta, which is released to the maternal circulation during pregnancy.
我们最近证实，在妊娠性瘙痒性荨麻疹性丘疹和斑块（PUPPP）中，存在多个真皮成纤维细胞且无黏蛋白沉积。我们认为，在PUPPP患者的真皮中存在一种诱导成纤维细胞增殖的物质沉积。我们推测这种物质（标记为F物质）是胎盘的产物，在怀孕期间释放到母体循环中。
