Aronson I K, Bond S, Fiedler V C, Vomvouras S, Gruber D, Ruiz C
Department of Dermatology, University of Illinois College of Medicine, Chicago 60612, USA.
J Am Acad Dermatol. 1998 Dec;39(6):933-9. doi: 10.1016/s0190-9622(98)70265-8.
Pruritic urticarial papules and plaques of pregnancy (PUPPP) has been described either as a homogeneous or a polymorphic clinical process. Its cause is unknown.
We attempted to characterize the clinical and immunopathologic findings in PUPPP on the basis of long-term clinical and immunopathologic observations.
The clinical and immunopathologic features of 57 patients with PUPPP were evaluated.
The clinical features in 57 patients with PUPPP were categorized into three types: mainly urticarial papules and plaques (type I), nonurticarial erythema, papules, or vesicles (type II), and combinations of the two forms (type III). Direct immunofluorescence studies in 48 of the 57 patients showed nonspecific immunoreactants in dermal blood vessels and/or moderate granular deposits at the dermoepidermal junction in 15 patients.
Type I PUPPP differed from types II and III in clinical appearance and distribution (absence of face, palm, and sole lesions), but trimester onset, parity, and direct immunofluorescence findings were not significantly different among the three groups.
妊娠性瘙痒性荨麻疹性丘疹和斑块（PUPPP）已被描述为一种单一或多形性临床过程。其病因尚不清楚。
基于长期的临床和免疫病理学观察，我们试图描述PUPPP的临床和免疫病理学表现。
对57例PUPPP患者的临床和免疫病理学特征进行评估。
57例PUPPP患者的临床特征分为三种类型：主要为荨麻疹性丘疹和斑块（I型）、非荨麻疹性红斑、丘疹或水疱（II型）以及两种形式的组合（III型）。57例患者中的48例进行直接免疫荧光研究，结果显示15例患者真皮血管中有非特异性免疫反应物和/或在真皮表皮交界处有中度颗粒状沉积物。
I型PUPPP在临床表现和分布（无面部、手掌和足底病变）上与II型和III型不同，但三组之间的孕期发作、产次和直接免疫荧光结果无显著差异。
