Trontelj J V, Fernandez J M
University Institute of Clinical Neurophysiology, University Medical Centre of Ljubjana, Yugoslavia.
Muscle Nerve. 1988 Apr;11(4):297-300. doi: 10.1002/mus.880110404.
A single fiber EMG (SFEMG) study was performed in 51 patients with idiopathic juvenile scoliosis of moderate degree (mean 23.8 degrees of Cobb), aged 7-18 years (mean 13.2 years). The findings in the extensor digitorum communis muscle (EDC) include a moderate but significant increase in fiber density (mean 2.02, +/- 0.21, P less than 0.001), a mild but significant (P less than 0.001) neuromuscular transmission abnormality (7.6% of fibers showed increased jitter and 4.5% intermittent blocking), and a moderately prolonged mean interspike interval (mean 0.98 msec, +/- 0.20, P less than 0.005) in EDC. Five of the patients had normal fiber density, 9 had a normal jitter study, and further 7 had a normal mean interspike interval. However only one had all the parameters normal. The paraspinal and intercostal muscles at the apex of the scoliotic curvature examined in some of the patients showed similar abnormalities. The study thus suggests the existence of a subclinical systemic neuromuscular disorder in nearly all of our patients with idiopathic scoliosis, which might have a pathogenetic significance.
对51例中度特发性青少年脊柱侧凸患者（Cobb角平均23.8度）进行了单纤维肌电图（SFEMG）研究，患者年龄7 - 18岁（平均13.2岁）。在指总伸肌（EDC）中的发现包括：纤维密度有中度但显著增加（平均2.02，±0.21，P < 0.001），存在轻度但显著的（P < 0.001）神经肌肉传递异常（7.6%的纤维显示抖动增加，4.5%出现间歇性阻滞），并且EDC中的平均峰间期适度延长（平均0.98毫秒，±0.20，P < 0.005）。5例患者纤维密度正常，9例抖动研究正常，另有7例平均峰间期正常。然而，只有1例所有参数均正常。部分患者脊柱侧凸弯曲顶点处的椎旁肌和肋间肌也显示出类似异常。该研究因此提示，几乎所有特发性脊柱侧凸患者均存在亚临床系统性神经肌肉疾病，这可能具有发病机制上的意义。
