Division of Obstetrics and Gynaecology, Oslo University Hospital, Ullevål, PB 4950, Nydalen, 0424, Oslo, Norway.
Faculty of Medicine, University of Oslo, Oslo, Norway.
Int Urogynecol J. 2021 Jul;32(7):1733-1743. doi: 10.1007/s00192-021-04836-5. Epub 2021 May 14.
Pregnancy and delivery are known risk factors for stress and mixed urinary incontinence. The most common surgical treatment is mid-urethral sling (MUS) surgery. This study evaluated the potential impact of the obstetrical history on the short-term subjective and objective failure rates after MUS surgery.
A registry-based surgical cohort study using data from the Medical Birth Registry of Norway (MBRN) and the national Norwegian Female Incontinence Registry (NFIR). Data from 14,787 women that underwent MUS surgery from 1998 to 2016 with complete registrations in the MBRN were included. Outcomes were 6-12-month postoperative subjective and objective failure rates. The potential impact of obstetrical and constitutional factors on both outcomes was tested in a multivariate logistic regression model.
Several obstetrical variables seemed to impact both outcomes in the univariate analyses. However, in the multivariate analyses, none of the obstetrical variables significantly impacted subjective failure, and only being nulliparous before MUS surgery remained a risk factor for objective failure [aOR 1.60, (95% CI 1.07-2.40), p = 0.022]. High body mass index at time of surgery, non-retropubic slings, high preoperative urgency symptom load, and surgical complications were all strong risk factors for poor outcomes in the multivariate analyses.
Although childbirth is considered a risk factor for developing stress urinary incontinence, childbirth does not appear to affect the result of MUS in parous women. Our results suggest that nulliparous women with SUI may have a different pathophysiology than SUI after childbirth.
妊娠和分娩是压力性和混合性尿失禁已知的风险因素。最常见的手术治疗方法是尿道中段吊带(MUS)手术。本研究评估了产科史对 MUS 手术后短期主观和客观失败率的潜在影响。
这是一项基于注册的手术队列研究,使用来自挪威医学出生登记处(MBRN)和全国挪威女性尿失禁登记处(NFIR)的数据。纳入了 1998 年至 2016 年间接受 MUS 手术且 MBRN 完整登记的 14787 名女性的数据。结果为术后 6-12 个月的主观和客观失败率。在多变量逻辑回归模型中测试了产科和体质因素对这两个结果的潜在影响。
在单变量分析中,几个产科变量似乎对两个结果都有影响。然而,在多变量分析中,产科变量均不显著影响主观失败,仅 MUS 手术前未生育是客观失败的危险因素[aOR 1.60,(95%CI 1.07-2.40),p=0.022]。手术时高体重指数、非经耻骨后吊带、术前急迫症状负荷高和手术并发症均是多变量分析中不良结局的强烈危险因素。
尽管分娩被认为是压力性尿失禁的危险因素,但分娩似乎不会影响经产妇 MUS 的结果。我们的结果表明,初产妇的 SUI 可能与产后 SUI 的病理生理学不同。