癌症中的泛素特异性肽酶22
Ubiquitin-specific peptidase 22 in cancer.
作者信息
Feng Tingting, Ling Sunbin, Xu Chenyang, Ying Lisha, Su Dan, Xu Xiao
机构信息
Department of Pathology, The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Basic Medicine and Cancer(IBMC), Chinese Academy of Sciences, Hangzhou, Zhejiang 310022, China; Cancer Research Institute, The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Basic Medicine and Cancer(IBMC), Chinese Academy of Sciences, Hangzhou, Zhejiang 310022, China; Department of Colorectal Medicine, The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Basic Medicine and Cancer(IBMC), Chinese Academy of Sciences, Hangzhou, Zhejiang 310022, China; Department of Hepatobiliary and Pancreatic Surgery, The Center for Integrated Oncology and Precision Medicine, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, China.
Department of Hepatobiliary and Pancreatic Surgery, The Center for Integrated Oncology and Precision Medicine, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, China.
出版信息
Cancer Lett. 2021 Aug 28;514:30-37. doi: 10.1016/j.canlet.2021.05.004. Epub 2021 May 11.
Recently, many studies have shown that deubiquitination modification of proteins is of great significance in major physiological processes such as cell proliferation, apoptosis, and differentiation. The ubiquitin-specific peptidase (USP) family is one of the most numerous and structurally diverse of the deubiquitinates known to date. USP22, an important member of the USP family, has been found to be closely associated with tumor cell cycle regulation, stemness maintenance, invasion and metastasis, chemoresistance, and immune regulation. We focus on recent advances regarding USP22's function in cancer and discuss the prospect of USP22 in this review.
最近，许多研究表明，蛋白质的去泛素化修饰在细胞增殖、凋亡和分化等主要生理过程中具有重要意义。泛素特异性蛋白酶（USP）家族是迄今为止已知的去泛素化酶中数量最多、结构最多样化的家族之一。USP22是USP家族的重要成员，已发现其与肿瘤细胞周期调控、干性维持、侵袭和转移、化疗耐药及免疫调节密切相关。在本综述中，我们重点关注USP22在癌症中功能的最新进展，并探讨USP22的研究前景。
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