1-苯基-2-丙酮肟在大鼠肝脏匀浆中的体外代谢
In vitro metabolism of 1-phenyl-2-propanone oxime in rat liver homogenates.
作者信息
Coutts R T, Dawe R, Dawson G W, Kovach S H
出版信息
Drug Metab Dispos. 1976 Jan-Feb;4(1):35-9.
PMID:3399
Abstract
1-Phenyl-2-propanone oxime is a known in vitro metabolite of amphetamine. Further in vitro metabolism of this oxime with the 12,000g supernatant fraction from homogenized rat liver gave one major and two minor metabolites which were identified as 2-nitro-1-phenylpropane, benzyl alcohol, and 1-phenyl-2-propanone, respectively, by means of combined gas chromatography and mass spectrometry, and by comparison with authentic samples of each product.
摘要
1-苯基-2-丙酮肟是苯丙胺一种已知的体外代谢物。该肟与来自大鼠肝脏匀浆的12,000g上清液部分进一步进行体外代谢，产生了一种主要代谢物和两种次要代谢物，通过气相色谱-质谱联用，并与每种产物的标准样品进行比较，分别鉴定为2-硝基-1-苯基丙烷、苯甲醇和1-苯基-2-丙酮。
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