From the Division of Infectious Disease, Department of Pediatrics, Medical School of Ege University, Izmir, Turkey.
Department of Virology, Faculty of Veterinary Medicine, Ankara, Turkey.
Pediatr Infect Dis J. 2021 Jul 1;40(7):e263-e265. doi: 10.1097/INF.0000000000003158.
COVID-19 spread globally and caused over 97 million cases with more than 2 million deaths. There is still ongoing discussion on the duration of infectious interval SARS-CoV-2 infection. Symptomatic children had longer virus shedding and there are some reports of prolonged infectious virus shedding in adults particularly patients having an immunocompromised status. A missense mutation, D614G, in the spike protein of SARS-CoV-2, which has emerged as a predominant clade in Europe and is spreading worldwide that can result in higher viral loads in patients. Herein, we described the longest infectious virus shedding in a previously healthy child infected with SARS-CoV-2 expressing spike D614G substitution.
COVID-19 在全球范围内传播,导致超过 9700 万例病例和超过 200 万人死亡。目前仍在讨论 SARS-CoV-2 感染的传染期持续时间。有症状的儿童病毒脱落时间更长,有一些关于成人(特别是免疫功能低下的患者)病毒持续脱落时间延长的报告。SARS-CoV-2 刺突蛋白中的一个错义突变 D614G,已经成为欧洲的主要分支,并在全球范围内传播,可能导致患者的病毒载量更高。在此,我们描述了一个先前健康的儿童感染 SARS-CoV-2 并表达刺突 D614G 取代物,病毒脱落时间最长的病例。