Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, 610041, China.
Department of Radiology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, 310000, China.
Transl Psychiatry. 2021 May 14;11(1):287. doi: 10.1038/s41398-021-01394-8.
Tourette syndrome (TS) is a neurobehavioral disorder for which the neurological mechanism has not been elucidated. Voxel-based morphometry (VBM) studies have revealed abnormalities in gray matter volume (GMV) in patients with TS; however, consistent results have not been obtained. The current study attempted to provide a voxel wise meta-analysis of gray matter changes using seed-based d mapping (SDM). We identified ten relevant studies that investigated gray matter alterations in TS patients and performed a meta-analysis using the SDM method to quantitatively estimate regional gray matter abnormalities. Next, we examined the relationships between GMV abnormalities and demographic and clinical characteristics. Our results demonstrated that TS patients had smaller GMV in the bilateral inferior frontal gyri and greater GMV in the cerebellum, right striatum (putamen), and bilateral thalami (pulvinar nucleus) than healthy controls. A meta-regression analysis did not identify correlations between GMV changes and demographic or clinical variables. This meta-analysis confirmed significant and consistent GMV changes in several brain regions of TS patients, primarily in the cortico-striato-thalamo-cortical network.
妥瑞氏综合征（TS）是一种神经行为障碍，其神经机制尚未阐明。体素形态计量学（VBM）研究显示，TS 患者的灰质体积（GMV）存在异常；然而，并未得到一致的结果。本研究试图使用基于种子的弥散度映射（SDM）对灰质变化进行基于体素的荟萃分析。我们确定了 10 项相关研究，这些研究调查了 TS 患者的灰质改变，并使用 SDM 方法进行荟萃分析，以定量估计区域性灰质异常。接下来，我们检查了 GMV 异常与人口统计学和临床特征之间的关系。我们的结果表明，与健康对照组相比，TS 患者的双侧额下回和小脑灰质体积较小，右侧纹状体（壳核）和双侧丘脑（丘脑枕核）灰质体积较大。元回归分析未发现 GMV 变化与人口统计学或临床变量之间的相关性。这项荟萃分析证实了 TS 患者几个脑区的 GMV 存在显著且一致的变化，主要是在皮质-纹状体-丘脑-皮质网络中。
