Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan, P.R. China.
Health Management Department, West China Hospital of Sichuan University, Chengdu, Sichuan, P.R. China.
PLoS One. 2018 Oct 10;13(10):e0203498. doi: 10.1371/journal.pone.0203498. eCollection 2018.
Studies using voxel-based morphometry report variable and inconsistent abnormalities of gray matter volume (GMV) and white matter volume (WMV) in brains of preterm-born adolescents (PBA). In such circumstances a meta-analysis can help identify the most prominent and consistent abnormalities.
We identified 9 eligible studies by systematic search of the literature up to October 2017. We used Seed-based d Mapping to analyze GMV and WMV alterations between PBA and healthy controls.
In the GMV meta-analysis, PBA compared to healthy controls showed: increased GMV in left cuneus cortex, left superior frontal gyrus, and right anterior cingulate cortex; decreased GMV in bilateral inferior temporal gyrus (ITG), left superior frontal gyrus, and right caudate nucleus. In the WMV meta-analysis, PBA showed: increased WMV in right fusiform gyrus and precuneus; decreased WMV in bilateral ITG, and right inferior frontal gyrus. In meta-regression analysis, the percentage of male PBA negatively correlated with decreased GMV of bilateral ITG.
PBA show widespread GMV and WMV alterations in the default mode network, visual recognition network, and salience network. These changes may be causally relevant to socialization difficulties and cognitive impairments. The meta-regression results perhaps reveal the structural underpinning of the cognition-related sex differences in PBA.
使用基于体素的形态计量学的研究报告显示，早产儿（PBA）大脑的灰质体积（GMV）和白质体积（WMV）存在变化且不一致。在这种情况下，荟萃分析可以帮助确定最突出和一致的异常。
我们通过系统搜索文献，截至 2017 年 10 月，确定了 9 项符合条件的研究。我们使用基于种子的 d 映射分析 PBA 与健康对照组之间 GMV 和 WMV 的改变。
在 GMV 荟萃分析中，与健康对照组相比，PBA 表现为：左侧楔前叶皮质、左侧额上回和右侧前扣带皮层 GMV 增加；双侧颞下回（ITG）、左侧额上回和右侧尾状核 GMV 减少。在 WMV 荟萃分析中，PBA 表现为：右侧梭状回和楔前叶 WMV 增加；双侧 ITG 和右侧额下回 WMV 减少。在元回归分析中，PBA 中男性比例与双侧 ITG 的 GMV 减少呈负相关。
PBA 在默认模式网络、视觉识别网络和突显网络中显示出广泛的 GMV 和 WMV 改变。这些变化可能与社交困难和认知障碍有关。元回归结果可能揭示了 PBA 中与认知相关的性别差异的结构基础。
