Chen Ru, Huang Zhi-Wei, Lin Xiao-Fen, Lin Jin-Fang, Yang Mei-Juan
Department of Urology, The First Hospital of Putian City, Putian, Fujian, China.
Department of Otolaryngology, Quanzhou First Hospital Affiliated to Fujian Medical University, Dongjie Road, Licheng District, Quanzhou, Fujian, 362000, People's Republic of China.
Sleep Breath. 2022 Mar;26(1):279-285. doi: 10.1007/s11325-021-02393-1. Epub 2021 May 15.
A relationship between albuminuria and obstructive sleep apnea (OSA) has been documented in previous studies. Nevertheless, the impact of continuous positive airway pressure (CPAP) treatment on albuminuria in subjects with OSA is debated. This meta-analysis was carried out to investigate whether or not CPAP treatment affected urinary albumin-to-creatinine ratio (UACR) in subjects with OSA.
A comprehensive literature search was conducted on Web of Science, Embase, and PubMed from January 1990 to December 2020. Information on patients' characteristics, features of the studies, and UACR of pre- and post-CPAP treatment was collected. For estimation of the pooled effects, standardized mean difference (SMD) was applied.
This meta-analysis included 6 articles and 211 subjects. The pooled analysis suggested that CPAP therapy exerted a favorable effect on the decrease of UACR in subjects with OSA (SMD = 0.415, 95% CI = 0.026 to 0.804, z = 2.09, p = 0.037). Subgroup analyses revealed that the CPAP treatment effect was not influenced by sample size, BMI, age, or AHI.
The present meta-analysis indicated that UACR was significantly reduced by CPAP therapy in subjects with OSA. Further well-designed randomized controlled trials with large sample size are required to confirm the benefits.
先前的研究已证实蛋白尿与阻塞性睡眠呼吸暂停（OSA）之间存在关联。然而，持续气道正压通气（CPAP）治疗对OSA患者蛋白尿的影响仍存在争议。本荟萃分析旨在研究CPAP治疗是否会影响OSA患者的尿白蛋白与肌酐比值（UACR）。
于2020年12月至1990年1月期间在Web of Science、Embase和PubMed上进行了全面的文献检索。收集了患者特征、研究特点以及CPAP治疗前后UACR的信息。为了估计合并效应，应用了标准化均值差（SMD）。
本荟萃分析纳入了6篇文章和211名受试者。汇总分析表明，CPAP治疗对降低OSA患者的UACR有显著效果（SMD = 0.415，95% CI = 0.026至0.804，z = 2.09，p = 0.037）。亚组分析显示，CPAP治疗效果不受样本量、BMI、年龄或AHI的影响。
本荟萃分析表明，CPAP治疗可使OSA患者的UACR显著降低。需要进一步开展设计良好的大样本随机对照试验来证实其益处。
