Department of Radiology, Children's Hospital of Philadelphia, 3401 Civic Center Blvd., Philadelphia, PA, 19104, USA.
Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Pediatr Radiol. 2021 Nov;51(12):2425-2436. doi: 10.1007/s00247-021-05095-8. Epub 2021 May 15.
The role of contrast-enhanced ultrasound (CEUS) imaging is being widely explored by various groups for its use in the pediatric population. Clinical implementation of new diagnostic or therapeutic techniques requires extensive and meticulous preclinical testing and evaluation. The impact of CEUS will be determined in part by the extent to which studies are oriented specifically toward a pediatric population. Rather than simply applying principles and techniques used in the adult population, these studies are expected to advance and augment preexisting knowledge with pediatric-specific information. To further develop this imaging modality for use in children, pediatric-focused preclinical research is essential. In this paper we describe the development and implementation of the pediatric-specific preclinical animal and phantom models that are being used to evaluate CEUS with the goal of clinical translation to children.
超声造影（CEUS）成像的作用正被不同的研究小组广泛探索，以应用于儿科人群。临床实施新的诊断或治疗技术需要广泛而细致的临床前测试和评估。CEUS 的影响在一定程度上将取决于研究是否专门针对儿科人群。这些研究不应简单地应用于成人人群中使用的原理和技术，而应期望用儿科特有的信息来推进和扩充已有知识。为了进一步开发这种成像模式在儿童中的应用，儿科重点的临床前研究至关重要。在本文中，我们描述了专门为儿科人群开发和实施的临床前动物和模型，这些模型正被用于评估 CEUS，以期将其临床应用于儿童。
