Department of Internal Medicine-Nephrology, "Grigore T. Popa" University of Medicine, Iasi, Romania.
Department of Morphofunctional Sciences-Histology, "Grigore T. Popa" University of Medicine, Iasi, Romania.
Int Urol Nephrol. 2022 Feb;54(2):365-376. doi: 10.1007/s11255-021-02881-z. Epub 2021 May 15.
The aim of this retrospective study was: to analyze the epidemiological patterns of the kidney disease based on clinical and histological features in a single-center in the N-E region of Romania, between 2011 and 2019 and to compare the biopsy results with the others periods, as well as the results from other countries.
We studied 442 renal biopsies. The indications for renal biopsy were represented by the clinical features: nephrotic syndrome, nephritic syndrome, asymptomatic urinary abnormalities, acute kidney injury, and chronic kidney disease of unknown etiology.
During the past 8 years, the annual incidence of renal biopsies was constant, albeit this incidence remained lower than in other countries. Nephrotic syndrome was the most common indication for renal biopsy (47.6%). Primary glomerulonephritis (GN) was the most common diagnosis in each of the three periods, followed by secondary GN. Vascular nephropathy and TIN were constant as a proportion from the overall biopsies in each of the three periods. The membranoproliferative GN (24.4%) and membranous nephropathy (MN) (21.9%) were the most prevalent primary GN, while lupus nephritis (LN) was the most common secondary glomerular disease in young female patients (7.5%). Compared to 1994-2004 period, we observed a significant decrease of incidence of focal segmental glomerulosclerosis (FSGS) and mesangial proliferative GN, and a significant increases in the frequency of MN.
The results of this study show that the GN distribution model was constant in N-E Romania and became similar to that observed in many countries with high socio-economic status.
本回顾性研究的目的是：分析 2011 年至 2019 年罗马尼亚东北部地区单中心基于临床和组织学特征的肾脏疾病的流行病学模式，并将活检结果与其他时期以及其他国家的结果进行比较。
我们研究了 442 例肾活检。肾活检的指征是临床表现：肾病综合征、肾炎综合征、无症状性尿异常、急性肾损伤和原因不明的慢性肾病。
在过去的 8 年中，肾活检的年发病率保持不变，尽管这一发病率仍低于其他国家。肾病综合征是肾活检最常见的指征（47.6%）。原发性肾小球肾炎（GN）是三个时期中每个时期最常见的诊断，其次是继发性 GN。血管性肾病和 TIN 在三个时期的每个时期中均保持不变，占总活检的比例。膜增生性 GN（24.4%）和膜性肾病（MN）（21.9%）是最常见的原发性 GN，而狼疮性肾炎（LN）是年轻女性患者中最常见的继发性肾小球疾病（7.5%）。与 1994-2004 年相比，我们观察到局灶节段性肾小球硬化症（FSGS）和系膜增生性 GN 的发病率显著下降，MN 的频率显著增加。
本研究结果表明，GN 分布模式在罗马尼亚东北部保持稳定，并变得与许多高社会经济地位国家观察到的模式相似。
