St. Mary's Medical Center, Huntington, WV; Department of Pharmacy Practice and Research, School of Pharmacy, Marshall University, Huntington, WV.
St. Mary's Medical Center, Huntington, WV.
Diagn Microbiol Infect Dis. 2021 Aug;100(4):115389. doi: 10.1016/j.diagmicrobio.2021.115389. Epub 2021 Apr 15.
Methicillin-resistant Staphylococcus aureus is a considerable pathogen in the setting of skin and soft tissue infections (SSTIs). MRSA PCR swab testing is widely used in the setting of respiratory tract infections, however little data exists relating to the use of MRSA PCR swab testing in SSTIs. Three thousand, nine hundred and ninety-five patients were included in this retrospective study that aimed to validate the clinical correlation of MRSA PCR wound swab testing in SSTIs through sensitivity, specificity, negative predictive value (NPV), and positive predictive value (PPV) analysis. From this review, MRSA PCR wound swabs were found to have a sensitivity of 97.6% (97.5-98.5), a specificity of 94.9% (94.3-95.7), a PPV of 92.3% (91.4-93.2), and a NPV of 98.4% (98.0-98.8). The study results demonstrate that the MRSA SSTI PCR assays have a high NPV and the potential to be a vital tool in de-escalating antimicrobial therapy associated with SSTIs.
耐甲氧西林金黄色葡萄球菌（MRSA）是皮肤和软组织感染（SSTI）中的一种重要病原体。MRSA PCR 拭子检测在呼吸道感染的情况下被广泛应用，但在 SSTI 中使用 MRSA PCR 拭子检测的相关数据较少。这项回顾性研究共纳入了 3995 名患者，旨在通过敏感性、特异性、阴性预测值（NPV）和阳性预测值（PPV）分析，验证 MRSA PCR 伤口拭子检测在 SSTI 中的临床相关性。从这项研究中发现，MRSA PCR 伤口拭子的敏感性为 97.6%（97.5-98.5），特异性为 94.9%（94.3-95.7），阳性预测值为 92.3%（91.4-93.2），阴性预测值为 98.4%（98.0-98.8）。研究结果表明，MRSA SSTI PCR 检测具有较高的 NPV，有可能成为降低与 SSTI 相关的抗菌治疗的重要工具。
