Institute on Membrane Technology, National Research Council, ITM-CNR, via P. Bucci, 17/C, I-87030 Rende (Cosenza), Italy.
King Abdullah University of Science and Technology (KAUST), Biological and Environmental Science and Engineering Division (BESE), Advanced Membranes and Porous Materials Center (AMPM), 23955-6900 Thuwal, Saudi Arabia.
Bioresour Technol. 2021 Sep;335:125248. doi: 10.1016/j.biortech.2021.125248. Epub 2021 May 4.
In this review, for the first time, the conjugation of the major types of enzymes used in biorefineries and the membrane processes to develop different configurations of MBRs, was analyzedfor the production of biofuels, phytotherapics and food ingredients. In particular, the aim is to critically review all the works related to the application of MBR in biorefinery, highlighting the advantages and the main drawbacks which can interfere with the development of this system at industrial scale. Alternatives strategies to overcome main limits will be also described in the different application fields, such as the use of biofunctionalized magnetic nanoparticles associated with membrane processes for enzyme re-use and membrane cleaning or the membrane fouling control by the use of integrated membrane process associated with MBR.
在本次综述中，首次分析了生物炼制厂中使用的主要类型的酶与膜过程的结合，以开发用于生产生物燃料、植物疗法药物和食品成分的不同配置的膜生物反应器。具体而言，目的是批判性地回顾与膜生物反应器在生物炼制厂中的应用相关的所有工作，强调可能会干扰该系统在工业规模上发展的优势和主要缺点。还将在不同的应用领域中描述克服主要限制的替代策略，例如将生物功能化磁性纳米粒子与膜过程结合使用以实现酶的再利用和膜清洁，或者通过使用与膜生物反应器集成的膜过程来控制膜污染。
