miRNAs 与癌症中表观遗传因子相互作用的最新综述

An Updated Review of the Cross-talk Between MicroRNAs and Epigenetic Factors in Cancers.

机构信息

Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran.

Department of Cellular and Molecular Biotechnology, Institute of Biotechnology, Urmia University, Urmia, Iran | Department of Biotechnology, Artemia and Aquaculture Research Institute, Urmia University, Urmia, Iran.

出版信息

Curr Med Chem. 2021;28(42):8722-8732. doi: 10.2174/0929867328666210514125955.

DOI:10.2174/0929867328666210514125955

PMID:33992051

Abstract

BACKGROUND

Growing evidence indicates that miRs have critical activities in adjusting cellular processes, e.g., cell death, proliferation, and cell-cycle.

INTRODUCTION

This study aimed to provide a concise review of the recent findings regarding tumoral miRs and the cross-talk between miRs and epigenetic factors.

RESULTS

Like the protein-coding genes, the expression levels of miRs are mediated by various transcriptional networks. Indeed, the expression of miRs could be epigenetically modulated by DNA methylation factors and histone modifiers. Furthermore, miRs can suppress critical factors, which mediate epigenetic modifications. Besides, miRs have been implicated in cancer development, metastasis, and chemo-resistance. The aberrant expression of miRs and dysregulated modulatory circuits between miRs and epigenetic factors participate in tumor progression.

CONCLUSION

Identifying tumoral miRs can provide ample opportunity to overcome chemo- resistance and bring a forefront treatment for affected patients.

摘要

背景

越来越多的证据表明，miRs 在调节细胞过程中具有关键作用，例如细胞死亡、增殖和细胞周期。

简介

本研究旨在简要综述最近关于肿瘤 miR 和 miR 与表观遗传因子之间相互作用的发现。

结果

与蛋白质编码基因一样，miRs 的表达水平受多种转录网络调控。事实上，miRs 的表达可以被 DNA 甲基化因子和组蛋白修饰因子表观遗传调控。此外，miRs 可以抑制介导表观遗传修饰的关键因子。此外，miRs 已被牵连到癌症的发展、转移和化疗耐药性中。miRs 的异常表达以及 miR 和表观遗传因子之间的调控回路失调参与了肿瘤的进展。