Unit of Experimental Therapeutics, Institute of Cancer Sciences, University of Glasgow, Wolfson Wohl Cancer Research Centre, Garscube Estate, Glasgow, G61 1QH, United Kingdom.
Academic Unit of Surgery, School of Medicine, University of Glasgow, Glasgow Royal Infirmary, Alexandria Parade, Glasgow, G31 2ER, United Kingdom.
Crit Rev Oncol Hematol. 2021 Jul;163:103337. doi: 10.1016/j.critrevonc.2021.103337. Epub 2021 May 13.
β-catenin is a key component of Wnt signalling, which plays a crucial role in CRC progression. Therefore, a meta-analysis was performed to assess the prognostic value of β-catenin expression in CRC patients. PubMed and Web of Science were searched for relevant publications referring to the association between β-catenin expression and outcome of CRC patients. Review Manager version 5.4 was employed to analysis data from 28 eligible studies (containing 5475 patients). Of these, 6 provided data on DFS, 6 provided data on CSS and 18 reports provided data on OS. High nuclear β-catenin expression was significantly associated with poorer DFS, CSS and OS in patients with CRC whereas, low membranous β-catenin expression was associated to poor OS. In conclusion, β-catenin has prognostic value and potential as a biomarker to stratify patients with CRC. However, further work with high quantity tissue cohorts and patient data is required to confirm this conclusion.
β-连环蛋白是 Wnt 信号通路的关键组成部分，在 CRC 进展中起着至关重要的作用。因此，进行了荟萃分析以评估β-连环蛋白表达在 CRC 患者中的预后价值。检索了 PubMed 和 Web of Science 以获取有关β-连环蛋白表达与 CRC 患者结局之间关联的相关出版物。使用 Review Manager 版本 5.4 分析了来自 28 项合格研究（包含 5475 名患者）的数据。其中 6 项提供了 DFS 数据，6 项提供了 CSS 数据，18 项报告提供了 OS 数据。高核β-连环蛋白表达与 CRC 患者的较差 DFS、CSS 和 OS 显著相关，而低膜β-连环蛋白表达与较差的 OS 相关。总之，β-连环蛋白具有预后价值，并有可能作为 CRC 患者分层的生物标志物。然而，需要进一步进行具有大量组织队列和患者数据的研究来证实这一结论。
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