Department of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
Department of Blood Transfusion, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
J Neuroimmunol. 2021 Jul 15;356:577604. doi: 10.1016/j.jneuroim.2021.577604. Epub 2021 May 7.
We aimed to evaluate the value of immunoadsorption (IA) treatment after the failure of intravenous methylprednisolone (IVMP) therapy for neuromyelitis optica spectrum disorder (NMOSD). Sixty-one NMOSD attacks unresponsive to IVMP were included: 22 patients received rescue IA (IVMP+IA), 24 underwent rescue plasma exchange (PE) (IVMP+PE), and 21 received no further rescue therapy (IVMP alone). The improvement frequencies were higher in the IVMP+IA and IVMP+PE groups than in the IVMP-alone group (P = 0.024). The effective period for IA treatment may be longer than previously thought. IA treatment for IVMP-resistant NMOSD attacks was effective and comparable to PE treatment.
我们旨在评估免疫吸附（IA）治疗在视神经脊髓炎谱系障碍（NMOSD）静脉注射甲基强的松龙（IVMP）治疗失败后的价值。共纳入 61 例对 IVMP 无反应的 NMOSD 发作：22 例患者接受挽救性 IA（IVMP+IA）治疗，24 例接受挽救性血浆置换（PE）（IVMP+PE）治疗，21 例未接受进一步挽救治疗（仅 IVMP）。IVMP+IA 和 IVMP+PE 组的改善频率均高于 IVMP 单药组（P=0.024）。IA 治疗的有效时间可能比之前认为的要长。IA 治疗对 IVMP 抵抗的 NMOSD 发作有效，与 PE 治疗相当。
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