Student Research Committee, Babol University of Medical Sciences, Babol, Iran.
Infertility and Reproductive Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Mazandaran, Iran.
Mol Biol Rep. 2021 Apr;48(4):3845-3851. doi: 10.1007/s11033-021-06196-1. Epub 2021 May 15.
Polycystic ovary syndrome (PCOS) is an endocrine disorder and affects 5-10% of reproductive-age women. Chronic anovulation, polycystic ovaries, and hyperandrogenism are the important features of this syndrome. Furthermore, hyperinsulinemia and central obesity are frequent in PCOS women. In recent years, noncoding RNAs detection provided new ideas to explain the etiology of female reproductive disorders. Long noncoding RNAs (lncRNAs) as a subset of noncoding RNAs are associated with the pathogenesis of manifold reproductive-related disorders. Various investigations emphasized the potential involvement of lncRNAs in PCOS development. Therefore, in this paper, we will summarize the function of numerous lncRNAs in the apoptosis and proliferation of granulosa cells (GCs), insulin resistance (IR), and steroidogenesis in PCOS.
多囊卵巢综合征（PCOS）是一种内分泌紊乱疾病，影响 5-10%的育龄妇女。该综合征的重要特征是慢性无排卵、多囊卵巢和高雄激素血症。此外，多囊卵巢综合征妇女常伴有高胰岛素血症和中心性肥胖。近年来，非编码 RNA 的检测为解释女性生殖障碍的病因提供了新的思路。长链非编码 RNA（lncRNA）作为非编码 RNA 的一个子集，与多种与生殖相关的疾病的发病机制有关。多项研究强调了 lncRNA 参与 PCOS 发展的潜在作用。因此，在本文中，我们将总结大量 lncRNA 在多囊卵巢综合征颗粒细胞（GCs）凋亡和增殖、胰岛素抵抗（IR）和类固醇生成中的作用。
