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注射用阿片类激动剂治疗:一个进化的概念分析。

Injectable opioid agonist treatment: An evolutionary concept analysis.

机构信息

Faculty of Health Sciences, School of Nursing, University of Ottawa, Ottawa, Ontario, Canada.

出版信息

Res Nurs Health. 2021 Aug;44(4):664-671. doi: 10.1002/nur.22140. Epub 2021 May 16.

DOI:10.1002/nur.22140
PMID:33993526
Abstract

Canada is currently in the midst of an overdose crisis. With new and innovative approaches desperately needed, injectable opioid agonist treatment (iOAT) should be considered as an integral treatment option to prevent even more fatalities. These programs provide injectable diacetylmorphine or hydromorphone to clients with severe opioid use disorders. Currently, they remain an under-executed and under-studied treatment modality. To better understand why this may be, we performed an evolutionary concept analysis as described by Rodgers. The attributes, antecedents, consequences, and surrogate terms of iOAT were unpacked and explored. Further, four themes were identified within the literature: (1) physical and mental health, (2) illicit drug use, (3) criminal behavior, and (4) ethical considerations. Recommendations surrounding the need for additional studies that focus on the perspectives of people who use opioids (PWUO), the necessity of nursing advocacy in iOAT, and the consideration of a changing illicit drug supply were explored. Further, theoretical analysis coupled with direct input from PWUO was discussed as a necessity to move forward with iOAT.

摘要

加拿大目前正处于阿片类药物过量危机之中。由于迫切需要新的创新方法,注射用阿片类激动剂治疗(iOAT)应该被视为一种完整的治疗选择,以防止更多的死亡。这些方案为有严重阿片类药物使用障碍的患者提供注射用二乙酰吗啡或氢吗啡酮。目前,它们仍然是一种执行不力和研究不足的治疗方式。为了更好地理解其中的原因,我们按照罗杰斯的描述进行了进化概念分析。对 iOAT 的属性、前因、后果和替代术语进行了剖析和探讨。此外,在文献中还确定了四个主题:(1)身心健康,(2)非法药物使用,(3)犯罪行为,(4)伦理考虑。探讨了围绕需要进行更多研究的建议,这些研究应侧重于使用阿片类药物的人的观点、在 iOAT 中护理倡导的必要性,以及考虑不断变化的非法毒品供应的问题。此外,还讨论了理论分析与使用阿片类药物者的直接投入相结合的必要性,以推进 iOAT 的发展。

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Injectable opioid agonist treatment: An evolutionary concept analysis.注射用阿片类激动剂治疗:一个进化的概念分析。
Res Nurs Health. 2021 Aug;44(4):664-671. doi: 10.1002/nur.22140. Epub 2021 May 16.
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Service delivery models for injectable opioid agonist treatment in Canada: 2 sequential environmental scans.加拿大注射用阿片类激动剂治疗的服务提供模式:2 项连续的环境扫描。
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Injectable opioid agonist treatment for opioid use disorder: a national clinical guideline.用于阿片类物质使用障碍的注射用阿片类激动剂治疗:一项国家临床指南。
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High Interest in Injectable Opioid Agonist Treatment With Hydromorphone Among Urban Syringe Service Program Participants.城市注射毒品者服务项目参与者对氢吗啡酮类注射阿片激动剂治疗有浓厚兴趣。
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Cost-effectiveness of hydromorphone for severe opioid use disorder: findings from the SALOME randomized clinical trial.氢吗啡酮治疗严重阿片类药物使用障碍的成本效益:来自 SALOME 随机临床试验的结果。
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引用本文的文献

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Harm Reduct J. 2024 Dec 31;21(1):230. doi: 10.1186/s12954-024-01135-2.
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Shaping and shifting schemas on supervised injectable opioid treatment: findings from a cross-sectional qualitative study in two German treatment facilities.在监督下注射类阿片治疗中塑造和改变模式:来自两家德国治疗机构的横断面定性研究结果。
Addict Sci Clin Pract. 2024 May 27;19(1):45. doi: 10.1186/s13722-024-00475-5.
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Supervised on-site dosing in injectable opioid agonist treatment-considering the patient perspective. Findings from a cross-sectional interview study in two German cities.
在注射用阿片类激动剂治疗中进行监督现场给药——从患者角度出发。在德国两个城市进行的横断面访谈研究的结果。
Harm Reduct J. 2023 Nov 1;20(1):162. doi: 10.1186/s12954-023-00896-6.
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'This is hardcore': a qualitative study exploring service users' experiences of Heroin-Assisted Treatment (HAT) in Middlesbrough, England.“这是铁杆的”:一项在英格兰米德尔斯堡探索服务使用者接受海洛因类药物维持治疗(HAT)体验的定性研究。
Harm Reduct J. 2023 May 12;20(1):66. doi: 10.1186/s12954-023-00785-y.