Cardiospecial Veterinary Hospital, Taipei, Taiwan, ROC.
Department of Companion Animals, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, Prince Edward Island, Canada.
J Vet Intern Med. 2021 Jul;35(4):1663-1672. doi: 10.1111/jvim.16156. Epub 2021 May 16.
Point-of-care (POC) N-terminal pro B-type natriuretic peptide (NT-proBNP) ELISA test has been evaluated for screening cats for cardiac disease in the referral veterinary setting but less is known about its use in general practice (GP).
To evaluate the diagnostic utility of a POC NT-proBNP ELISA in cats seen in GPs.
Two hundred and seventeen apparently healthy cats from 21 GPs.
This was a prospective, cross-sectional study. Cardiac auscultation and POC NT-proBNP ELISA were done by veterinarians at their GPs. After enrollment at GPs, cats were sent to a cardiology referral hospital for cardiac auscultation and echocardiographic diagnosis. Results were interpreted based on whether cats had normal or abnormal echocardiographic findings.
Point-of-care NT-proBNP ELISA results differentiated cats in the abnormal group from those in the normal group with a sensitivity of 43%, specificity of 96%. In cats with a heart murmur at GPs, POC NT-proBNP ELISA results differentiated cats in the abnormal group from those in the normal group with a sensitivity of 71% and a specificity of 92%.
In apparently healthy cats in GPs, positive POC NT-proBNP results are associated with heart disease, warranting an echocardiogram, but negative results do not reliably exclude heart disease. These results suggest POC NT-proBNP is not an effective screening test for apparently healthy cats in GPs, although its performance is improved if it is used only in cats that have a heart murmur.
床边即时检测（POC）N 端脑利钠肽前体（NT-proBNP）ELISA 检测已被用于筛选兽医转诊环境中患有心脏病的猫，但在一般实践（GP）中使用的情况知之甚少。
评估 POC NT-proBNP ELISA 在 GP 中用于检查猫的心脏疾病的诊断效用。
21 名兽医在 21 名 GP 处检查的 217 只貌似健康的猫。
这是一项前瞻性的横断面研究。兽医在 GP 处进行心脏听诊和 POC NT-proBNP ELISA。在 GP 处登记后，将猫送往心脏病转诊医院进行心脏听诊和超声心动图诊断。结果根据猫是否有正常或异常的超声心动图结果进行解释。
POC NT-proBNP ELISA 结果可将异常组的猫与正常组的猫区分开来，敏感性为 43%，特异性为 96%。在 GP 处有心脏杂音的猫中，POC NT-proBNP ELISA 结果可将异常组的猫与正常组的猫区分开来，敏感性为 71%，特异性为 92%。
在 GP 中貌似健康的猫中，阳性 POC NT-proBNP 结果与心脏病相关，需要进行超声心动图检查，但阴性结果不能可靠地排除心脏病。这些结果表明，POC NT-proBNP 不是 GP 中貌似健康的猫的有效筛查试验，尽管如果仅在有心脏杂音的猫中使用，其性能会有所提高。
