Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan.
Department of Microbiology, NYU School of Medicine, NY, USA.
FEBS J. 2022 Jul;289(13):3642-3654. doi: 10.1111/febs.16017. Epub 2021 May 31.
Membrane-associated RING-CH (MARCH) family member proteins are RING-finger E3 ubiquitin ligases that are known to downregulate cellular transmembrane proteins. MARCH8 is a novel antiviral factor that inhibits HIV-1 envelope glycoprotein and vesicular stomatitis virus G by downregulating these envelope glycoproteins from the cell surface, resulting in their reduced incorporation into virions. More recently, we have found that MARCH8 reduces viral infectivity via two different mechanisms. Additionally, several groups have reported further antiviral or virus-supportive functions of the MARCH8 protein and its other cellular mechanisms. In this review, we summarize the current knowledge about the molecular mechanisms by which MARCH8 can regulate cellular homeostasis and inhibit and occasionally support enveloped virus infection.
膜相关环指 E3 泛素连接酶家族成员蛋白是 RING 指 E3 泛素连接酶，已知其可下调细胞跨膜蛋白。MARCH8 是一种新型抗病毒因子，通过下调细胞表面的这些包膜糖蛋白，从而减少它们整合到病毒粒子中，来抑制 HIV-1 包膜糖蛋白和水疱性口炎病毒 G。最近，我们发现 MARCH8 通过两种不同的机制降低病毒感染力。此外，有几个小组已经报道了 MARCH8 蛋白及其它细胞机制的进一步抗病毒或支持病毒的功能。在这篇综述中，我们总结了 MARCH8 调节细胞内稳态以及抑制和偶尔支持包膜病毒感染的分子机制的最新知识。
