Shumkov V A, Zagorodnikova K A, Boldueva S A, Murzina A A, Petrova V B
I.I.Mechnikov North-Western State Medical University, 41 Kirochnaya str., St. Petersburg 191015, Russian Federation, e-mail:
Adv Gerontol. 2021;34(1):48-53.
We have analyzed influence of genetic variants CYP2D63 (2549delA) and CYP2D64 (1846G>A), as well as other factors on effects of bisoprolol in patients with acute coronary syndrome. The study included 97 patients with acute coronary syndrome. Mean age was 63±10 years; 60 men and 37 women. We have found association between carriage of CYP2D64 (1846G>A) and maximal heart rate at exertion (R-0,21; р<0,05). When the correction for potential confounders was made, age was the only significant predictor of maximal heart rate (β=0,6; SE=0,07; p<0,001). At the same time it was found that CYP2D64 was associated with more advanced age of the patients (r=0,2; p<0,05).
我们分析了基因变异CYP2D63（2549delA）和CYP2D64（1846G>A）以及其他因素对急性冠脉综合征患者比索洛尔疗效的影响。该研究纳入了97例急性冠脉综合征患者。平均年龄为63±10岁；男性60例，女性37例。我们发现携带CYP2D64（1846G>A）与运动时的最大心率之间存在关联（R=-0.21；p<0.05）。在对潜在混杂因素进行校正后，年龄是最大心率的唯一显著预测因素（β=-0.6；标准误=0.07；p<0.001）。同时发现，CYP2D64与患者年龄较大有关（r=0.2；p<0.05）。
