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药理学和遗传学阻断颈动脉体中的 可治疗肥胖引起的高血压。

Pharmacological and Genetic Blockade of in the Carotid Body Treats Obesity-Induced Hypertension.

机构信息

From the Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD (M.-K.S., C.G., L.J.K., R.L., L.P., J.S.K.S., V.Y.P.).

Department of Chemical and Biomolecular Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD (R.M., H.C.).

出版信息

Hypertension. 2021 Jul;78(1):104-114. doi: 10.1161/HYPERTENSIONAHA.120.16527. Epub 2021 May 17.

DOI:10.1161/HYPERTENSIONAHA.120.16527
PMID:33993722
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8192446/
Abstract

[Figure: see text].

摘要

[图：见正文]。

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本文引用的文献

[1]
Carotid Body and Metabolic Syndrome: Mechanisms and Potential Therapeutic Targets.

Int J Mol Sci. 2020-7-20

[2]
Experimental Approach to Examine Leptin Signaling in the Carotid Bodies and its Effects on Control of Breathing.

J Vis Exp. 2019-10-25

[3]
CircaCompare: a method to estimate and statistically support differences in mesor, amplitude and phase, between circadian rhythms.

Bioinformatics. 2020-2-15

[4]
Leptin Induces Hypertension Acting on Transient Receptor Potential Melastatin 7 Channel in the Carotid Body.

Circ Res. 2019-9-23

[5]
Sex and Body Mass Index Modify the Association Between Leptin and Sodium Excretion: A Cross-sectional Study in an African Population.

Am J Hypertens. 2019-10-16

[6]
Plasma leptin level is positively associated with blood pressure measures independent of gender and BMI.

Clin Exp Hypertens. 2018-12-22

[7]
Prevalence of Apparent Treatment-Resistant Hypertension in the United States.

Hypertension. 2019-2

[8]
Leptin acts in the carotid bodies to increase minute ventilation during wakefulness and sleep and augment the hypoxic ventilatory response.

J Physiol. 2018-11-29

[9]
Modulation of Sympathetic Overactivity to Treat Resistant Hypertension.

Curr Hypertens Rep. 2018-9-7

[10]
Integrating loop gain into the understanding of obstructive sleep apnoea mechanisms.

J Physiol. 2018-9

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