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Leptin receptor downregulation in the carotid body treats obesity-induced hypertension.
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Hypoxia inducible factor-dependent upregulation of Agrp in glomus type I cells of the carotid body.
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Mechanisms and treatment of obesity-related hypertension-Part 1: Mechanisms.
Clin Kidney J. 2023 Nov 13;17(1):sfad282. doi: 10.1093/ckj/sfad282. eCollection 2024 Jan.
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Carotid body denervation improves hyperglycemia in obese mice.
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Carotid Body Dysfunction and Mechanisms of Disease.
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Carotid body: an emerging target for cardiometabolic co-morbidities.
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TRPM7 channels regulate breathing during sleep in obesity by acting peripherally in the carotid bodies.
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Carotid Body and Metabolic Syndrome: Mechanisms and Potential Therapeutic Targets.
Int J Mol Sci. 2020 Jul 20;21(14):5117. doi: 10.3390/ijms21145117.
4
Leptin Induces Hypertension Acting on Transient Receptor Potential Melastatin 7 Channel in the Carotid Body.
Circ Res. 2019 Nov 8;125(11):989-1002. doi: 10.1161/CIRCRESAHA.119.315338. Epub 2019 Sep 23.
6
Plasma leptin level is positively associated with blood pressure measures independent of gender and BMI.
Clin Exp Hypertens. 2020;42(1):31-35. doi: 10.1080/10641963.2018.1557684. Epub 2018 Dec 22.
7
Prevalence of Apparent Treatment-Resistant Hypertension in the United States.
Hypertension. 2019 Feb;73(2):424-431. doi: 10.1161/HYPERTENSIONAHA.118.12191.
9
Modulation of Sympathetic Overactivity to Treat Resistant Hypertension.
Curr Hypertens Rep. 2018 Sep 7;20(11):92. doi: 10.1007/s11906-018-0893-8.
10
Integrating loop gain into the understanding of obstructive sleep apnoea mechanisms.
J Physiol. 2018 Sep;596(17):3819-3820. doi: 10.1113/JP276590. Epub 2018 Jul 23.

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