Nuclear Medicine, IRCCS - Humanitas Research Hospital, Rozzano MI, Italy.
Department of Nuclear Medicine, University Hospital and Medical Faculty, University of Cologne, Cologne, University of Cologne, Cologne, Germany.
Semin Nucl Med. 2021 Sep;51(5):458-473. doi: 10.1053/j.semnuclmed.2021.04.002. Epub 2021 May 11.
2-deoxy-2-[F]fluoro-D-glucose [F]FDG-PET/CT represents the metabolic imaging of choice in various cancer types. Used either at diagnosis or during treatment response assessment, the modality allows for a more accurate definition of tumor extent compared to morphological imaging and is able to predict the therapeutic benefit earlier in time. Due to the aspecific uptake property of [F]FDG there is an overlap of its distribution in normal and pathological conditions, which can make the interpretation of the imaging challenging. Lung and pleural neoplasia are no exception to this, thus acknowledging of possible pitfalls and artifacts are mandatory for image interpretation. While most pitfalls and artifacts are common for all indications with metabolic imaging with [F]FDG-PET/CT, there are specific variants and pitfalls in lung cancer and malignant pleural mesothelioma. The aim of the present article is to shed light on the most frequent and relevant variants and pitfalls in [F]FDG-PET/CT imaging in lung cancer and malignant pleural mesothelioma.
2-脱氧-2-[F]氟代-D-葡萄糖 [F]FDG-PET/CT 是各种癌症类型的代谢成像的首选方法。无论是在诊断时还是在治疗反应评估期间使用，该方法都能比形态学成像更准确地定义肿瘤范围，并能够更早地预测治疗效果。由于 [F]FDG 的摄取特性是非特异性的，因此其在正常和病理情况下的分布存在重叠，这可能会使影像学解释具有挑战性。肺部和胸膜肿瘤也不例外，因此，对于图像解释来说，认识到可能的陷阱和伪影是强制性的。虽然大多数陷阱和伪影在所有使用 [F]FDG-PET/CT 进行代谢成像的适应证中都是常见的，但在肺癌和恶性胸膜间皮瘤中存在特定的变体和陷阱。本文的目的是阐明肺癌和恶性胸膜间皮瘤中 [F]FDG-PET/CT 成像中最常见和相关的变体和陷阱。
