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在坦桑尼亚使用海洛因的女性样本中,目睹阿片类药物过量的发生率很高:对预防过量的影响。

High occurrence of witnessing an opioid overdose in a sample of women who use heroin in Tanzania: Implications for overdose prevention.

机构信息

Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, 615 North Wolfe Street, Baltimore, MD 21205, USA.

Department of Epidemiology and Biostatistics, School of Public Health and Social Sciences, Muhimbili University of Health and Allied Sciences, P.O. Box 65015, Dar es Salaam, Tanzania; Department of Psychiatry and Mental Health, School of Medicine, Muhmbili University of Health and Allied Sciences, P.O. Box 65001, Dar es Salaam, Tanzania.

出版信息

Int J Drug Policy. 2021 Oct;96:103287. doi: 10.1016/j.drugpo.2021.103287. Epub 2021 May 14.

Abstract

BACKGROUND

Opioid overdose is preventable and reversible. To target overdose prevention training and naloxone distribution, it is important to understand characteristics of those people who use drugs most likely to witness an overdose. In this paper we report the proportion and characteristics of women who use heroin that have witnessed an opioid overdose in Dar es Salaam, Tanzania.

METHODS

We conducted a cross-sectional survey with 200 women who use heroin. We fitted unadjusted and adjusted logistic regression models with witnessing an opioid overdose as the dependent variable and sociodemographic and drug use-related variables as independent variables.

RESULTS

The majority of participants (85%) reported having ever witnessed an opioid overdose. Age (adjusted Odds Ratio [aOR] = 1.09; 95% CI: 1.02-1.12), having ever attempted to stop heroin use (aOR = 11.27; 95% CI: 2.25-56.46), history of arrest (aOR = 3.75; 95% CI: 1.32-10.63), and spending time daily in places where people use drugs (aOR = 3.72; 95% CI: 1.43-9.64) were found to be independently associated with ever witnessing an overdose.

CONCLUSIONS

Findings suggest the need for expanded access to naloxone to lay people and community and peer-based overdose prevention training in Tanzania, including the distribution of naloxone in settings with high drug use.

摘要

背景

阿片类药物过量是可预防和可逆转的。为了针对过量预防培训和纳洛酮的分发,了解最有可能目睹过量的吸毒者的特征很重要。在本文中,我们报告了在坦桑尼亚达累斯萨拉姆,目睹阿片类药物过量的女性海洛因使用者的比例和特征。

方法

我们对 200 名女性海洛因使用者进行了横断面调查。我们将目击阿片类药物过量作为因变量,并将社会人口统计学和吸毒相关变量作为自变量,拟合未经调整和调整后的逻辑回归模型。

结果

大多数参与者(85%)报告曾目睹过阿片类药物过量。年龄(调整后的优势比[aOR] = 1.09;95%置信区间:1.02-1.12)、曾经试图停止使用海洛因(aOR = 11.27;95%置信区间:2.25-56.46)、有过被捕经历(aOR = 3.75;95%置信区间:1.32-10.63)和每天在吸毒者常去的地方花费时间(aOR = 3.72;95%置信区间:1.43-9.64)被发现与曾目击过过量有关。

结论

研究结果表明,坦桑尼亚需要扩大纳洛酮的使用范围,包括在吸毒者密集的地方分发纳洛酮,并开展针对普通民众和社区以及同伴的基于 overdose 预防培训。

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