Hansen P B, Waldorff S, Hjelms E, Steiness E, Diamant B
Department of Cardio-Thoracic Surgery R, Rigshospitalet, Copenhagen, Denmark.
Pharmacol Toxicol. 1988 Jul;63(1):33-6. doi: 10.1111/j.1600-0773.1988.tb00905.x.
The combined effect of terbutaline on systemic and coronary circulation was investigated in dogs to clarify its influence on myocardial oxygen supply and lactate balance. The dogs were anaesthetized and the chest opened. Coronary sinus blood flow and cardiac output were monitored by thermodilution, aortic pressure was measured by tip-transducer and heart rate by RR-interval on ECG, coronary sinus blood were analyzed for lactate, oxygen and carbon dioxide. Terbutaline caused a substantial systemic vasodilation and an increased heart rate, the total external cardiac work increased to a minor degree. Terbutaline increased arterial lactate concentration. Coronary vascular resistance was reduced after terbutaline. Even if myocardial perfusion pressure was reduced and an increased external cardiac work was present, no signs of myocardial distress was observed in lactate metabolism or coronary sinus oxygen content. In fact a tendency to increased myocardial aerobic metabolism was observed, as myocardial lactate consumption increased after terbutaline. Terbutaline seems to be a coronary vasodilator in dogs. However, the demand for oxygen secondary to both an increase in cardiac work and aerobic metabolism can be hazardous to the potentially ischaemic myocardium.
研究了特布他林对犬全身和冠状动脉循环的联合作用，以阐明其对心肌氧供应和乳酸平衡的影响。将犬麻醉并打开胸腔。通过热稀释法监测冠状窦血流量和心输出量，通过顶端换能器测量主动脉压，通过心电图上的RR间期测量心率，分析冠状窦血中的乳酸、氧和二氧化碳含量。特布他林引起显著的全身血管舒张和心率增加，心脏总外部功略有增加。特布他林使动脉乳酸浓度升高。特布他林给药后冠状动脉血管阻力降低。即使心肌灌注压降低且存在心脏外部功增加的情况，但在乳酸代谢或冠状窦氧含量方面未观察到心肌窘迫的迹象。事实上，观察到心肌有氧代谢有增加的趋势，因为特布他林给药后心肌乳酸消耗量增加。特布他林在犬中似乎是一种冠状动脉血管舒张剂。然而，由于心脏功增加和有氧代谢增加导致的氧需求可能对潜在缺血心肌有害。
