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Front Endocrinol (Lausanne). 2021 Apr 30;12:642928. doi: 10.3389/fendo.2021.642928. eCollection 2021.
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Cardiovascular Disease-Associated MicroRNAs as Novel Biomarkers of First-Trimester Screening for Gestational Diabetes Mellitus in the Absence of Other Pregnancy-Related Complications.心血管疾病相关 microRNAs 作为无其他妊娠相关并发症的妊娠期糖尿病第一孕期筛查的新型生物标志物。
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本文引用的文献

1
Increased leptin, decreased adiponectin and FGF21 concentrations in adolescent offspring of women with gestational diabetes.妊娠糖尿病妇女的青春期后代瘦素增加、脂联素和 FGF21 浓度降低。
Eur J Endocrinol. 2019 Dec;181(6):691-700. doi: 10.1530/EJE-19-0658.
2
Gestational diabetes mellitus and risk of incident primary cancer: A population-based retrospective cohort study.妊娠糖尿病与原发性癌症发病风险：基于人群的回顾性队列研究。
J Diabetes. 2020 Jan;12(1):87-90. doi: 10.1111/1753-0407.12988. Epub 2019 Oct 17.
3
Intrauterine Device Use and Ovarian Cancer Risk: A Systematic Review and Meta-analysis.宫内节育器使用与卵巢癌风险：系统评价和荟萃分析。
Obstet Gynecol. 2019 Oct;134(4):791-800. doi: 10.1097/AOG.0000000000003463.
4
Associations of pregnancy-related factors and birth characteristics with risk of endometrial cancer: A Nordic population-based case-control study.与妊娠相关因素和出生特征相关的子宫内膜癌风险：一项基于北欧人群的病例对照研究。
Int J Cancer. 2020 Mar 15;146(6):1523-1531. doi: 10.1002/ijc.32494. Epub 2019 Jun 20.
5
Hormonal Changes Associated With Intra-Uterine Growth Restriction: Impact on the Developing Brain and Future Neurodevelopment.与子宫内生长受限相关的激素变化：对发育中大脑及未来神经发育的影响
Front Endocrinol (Lausanne). 2019 Mar 26;10:179. doi: 10.3389/fendo.2019.00179. eCollection 2019.
6
Incidence and relative risk for developing cancers in women with gestational diabetes mellitus: a nationwide cohort study in Taiwan.妊娠糖尿病女性癌症发病风险及相对危险度：台湾全国队列研究。
BMJ Open. 2019 Feb 21;9(2):e024583. doi: 10.1136/bmjopen-2018-024583.
7
Age at First Birth and the Risk of Endometrial Cancer Incidence: A Pooled Analysis of Two Prospective Cohort Studies among Japanese Women.初产年龄与子宫内膜癌发病风险：日本女性两项前瞻性队列研究的汇总分析
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8
Evaluation of the Association between Gestational Diabetes Mellitus at First Pregnancy and Cancer within 10 Years Postpartum Using National Health Insurance Data in South Korea.利用韩国国家健康保险数据评估初产妇妊娠期糖尿病与产后 10 年内癌症之间的关联。
Int J Environ Res Public Health. 2018 Nov 26;15(12):2646. doi: 10.3390/ijerph15122646.
9
Abnormal steroidogenesis and aromatase activity in preeclampsia.子痫前期中的异常甾体生成和芳香化酶活性。
Placenta. 2018 Sep;69:40-49. doi: 10.1016/j.placenta.2018.07.004. Epub 2018 Jul 7.
10
Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.全球癌症统计数据 2018：GLOBOCAN 对全球 185 个国家/地区 36 种癌症的发病率和死亡率的估计。
CA Cancer J Clin. 2018 Nov;68(6):394-424. doi: 10.3322/caac.21492. Epub 2018 Sep 12.

妊娠并发症与子宫内膜癌或卵巢癌发病风险：病例对照研究。

Complications of Pregnancy and the Risk of Developing Endometrial or Ovarian Cancer: A Case-Control Study.

机构信息

School of Medicine, Nanjing Medical University, Nanjing, China.

Department of Obstetrics & Gynaecology, The University of Auckland, Auckland, New Zealand.

出版信息

Front Endocrinol (Lausanne). 2021 Apr 30;12:642928. doi: 10.3389/fendo.2021.642928. eCollection 2021.

DOI:10.3389/fendo.2021.642928
PMID:33995276
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8121171/
Abstract

BACKGROUND

The association of complications of pregnancy and the risk of developing gynecological cancer is controversial with the limited study. In this study, we investigated the association of preeclampsia, or gestational diabetes mellitus (GDM), or large for gestational age (LGA), or intrauterine growth restriction (IUGR) and the risk of endometrial or ovarian cancer.

METHODS

In this case-control study, 189 women with endometrial cancer and 119 women with ovarian cancer were included. 342 women without gynecological cancers were randomly selected as a control group. Data on the history of pregnancy and age at diagnosis of gynecological cancer as well as the use of intrauterine devices (IUDs) were collected.

RESULTS

Women with a history of preeclampsia or IUGR did not have an increased risk of developing endometrial or ovarian cancer. While women with a history of GDM or with the delivery of LGA infant increased the risk of developing endometrial cancer but not ovarian cancer. The odds of women with a history of GDM or with the delivery of LGA infant developing endometrial cancer was 2.691 (95% CI: 1.548, 4.3635, p=0.0003), or 6.383 (95% CI: 2.812, 13.68, p<0.0001) respectively, compared to the controls. The odds ratio of women who did not use IUDs developing ovarian cancer was 1.606 (95% CI: 1.057, 2.434), compared to the controls. There was no association of age at first birth and developing endometrial or ovarian cancer.

CONCLUSION

Our observational data suggested that GDM and delivery of an LGA infant are associated with an increased risk of endometrial cancer.

摘要

背景

妊娠并发症与妇科癌症风险之间的关联存在争议，相关研究有限。本研究旨在探讨子痫前期、妊娠期糖尿病（GDM）、巨大儿（LGA）或宫内生长受限（IUGR）与子宫内膜癌或卵巢癌风险之间的关联。

方法

本病例对照研究纳入了 189 例子宫内膜癌患者和 119 例卵巢癌患者。随机选择 342 例无妇科癌症的女性作为对照组。收集了患者的妊娠史、妇科癌症诊断年龄以及宫内节育器（IUD）使用情况等数据。

结果

患有子痫前期或 IUGR 的女性发生子宫内膜癌或卵巢癌的风险并未增加。而患有 GDM 或分娩 LGA 婴儿的女性发生子宫内膜癌的风险增加，但不增加卵巢癌风险。患有 GDM 或分娩 LGA 婴儿的女性发生子宫内膜癌的风险比对照组分别增加了 2.691 倍（95%CI：1.548，4.3635，p=0.0003）和 6.383 倍（95%CI：2.812，13.68，p<0.0001）。与对照组相比，未使用 IUD 的女性发生卵巢癌的风险比为 1.606（95%CI：1.057，2.434）。初产年龄与子宫内膜癌或卵巢癌发生风险无关联。

结论

本观察性数据提示 GDM 和 LGA 婴儿分娩与子宫内膜癌风险增加相关。