Chen Mengxi, Liu Huan, Li Zhang, Ming Alex Lau, Chen Honglei
Department of Pathology, Zhongnan Hospital of Wuhan University, Wuhan 430071, P. R. China.
Department of Pathology, School of Basic Medical Sciences, Wuhan University, Wuhan 430071, P. R. China.
J Cancer. 2021 Apr 24;12(12):3566-3574. doi: 10.7150/jca.54430. eCollection 2021.
PKM2 is the enzyme that regulates the final rate-limiting step of glycolysis. PKM2 expression can reinforce the utilization of oxygen and synthesis of growth substances in cancer cells by enhancing OXPHOS and the Warburg effect. In cancer immunity, PKM2 can modulate the expression of PD-L1 in M2 macrophage and decrease the amount and activity of CD8 T cells. This affects cancer cell killing and immune escape sequentially. How PKM2 regulates PD-L1 expression through immunometabolism is summarized. PKM2 builds a bridge between energy metabolism and cancer immunity. The activator and inhibitor of PKM2 both promote the anti-cancer immune response and inhibit cancer growth and metastasis by regulating the metabolism of cancer cells and immune cells in the tumor microenvironment through HIF-1α/PKM2 pathway. This review focuses on the precise role of PKM2 modulating immunometabolism, providing valuable suggestions for further study in this field.
丙酮酸激酶M2（PKM2）是调节糖酵解最终限速步骤的酶。PKM2的表达可通过增强氧化磷酸化（OXPHOS）和瓦伯格效应来加强癌细胞中氧的利用和生长物质的合成。在癌症免疫中，PKM2可调节M2巨噬细胞中程序性死亡受体配体1（PD-L1）的表达，并减少CD8 T细胞的数量和活性。这依次影响癌细胞杀伤和免疫逃逸。总结了PKM2如何通过免疫代谢调节PD-L1表达。PKM2在能量代谢和癌症免疫之间架起了一座桥梁。PKM2的激活剂和抑制剂均通过缺氧诱导因子-1α（HIF-1α）/PKM2途径调节肿瘤微环境中癌细胞和免疫细胞的代谢，从而促进抗癌免疫反应并抑制癌症生长和转移。本综述着重于PKM2调节免疫代谢的确切作用，为该领域的进一步研究提供有价值的建议。
Zotero 插件
