冠状动脉疾病患者血清中二十碳五烯酸和花生四烯酸的浓度与认知功能
Serum Eicosapentaenoic and Arachidonic Acids Concentration and Cognitive Function in Patients With Coronary Artery Disease.
作者信息
Yoosefee Sadegh, Rahimi Maryam, Razavinia Fatemeh Sadat, Vahedian Mostafa, Bagheri Ahmad Reza
机构信息
Neurosciences Research Center, Qom University of Medical Sciences, Qom, Iran.
Spiritual Health Research Center, Qom University of Medical Sciences, Qom, Iran.
出版信息
Basic Clin Neurosci. 2021 Jan-Feb;12(1):63-68. doi: 10.32598/bcn.12.1.606.3. Epub 2021 Jan 1.
INTRODUCTION
Recent studies have shown that Polyunsaturated Fatty Acids (PUFAs), including Eicosapentaenoic Acid (EPA), and Arachidonic Acid (AA), are associated with cognitive functions in patients with Coronary Artery Disease (CAD). Nevertheless, controversial results have been reported, too. The current study aimed to clarify the association of serum EPA and AA levels with cognitive decline in an Iranian sample with CAD.
METHODS
We evaluated cognitive function with the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA), in relation to serum levels of EPA and AA, in 179 CAD patients. The associations between the MMSE and MoCA scores and the other demographic parameters were evaluated.
RESULTS
Patients with CAD generally had mild cognitive impairment. But we could not find any significant correlation between PUFAs and cognitive function. However, BMI was associated with EPA/MoCA; age was associated with MMSE/MoCA and BMI. Finally, the correlation between sex and MMSE/MoCA was significant.
CONCLUSION
Subjects generally had mild cognitive impairment, but we could not find any significant correlation between serum EPA and AA levels with cognitive function.
引言
最近的研究表明，多不饱和脂肪酸（PUFAs），包括二十碳五烯酸（EPA）和花生四烯酸（AA），与冠状动脉疾病（CAD）患者的认知功能有关。然而，也有相互矛盾的研究结果报道。本研究旨在阐明伊朗CAD患者样本中血清EPA和AA水平与认知功能下降之间的关联。
方法
我们使用简易精神状态检查表（MMSE）和蒙特利尔认知评估量表（MoCA）评估了179例CAD患者的认知功能，并将其与血清EPA和AA水平进行关联分析。我们还评估了MMSE和MoCA评分与其他人口统计学参数之间的关联。
结果
CAD患者普遍存在轻度认知障碍。但我们未发现PUFAs与认知功能之间存在任何显著相关性。然而，BMI与EPA/MoCA相关；年龄与MMSE/MoCA及BMI相关。最后，性别与MMSE/MoCA之间存在显著相关性。
结论
研究对象普遍存在轻度认知障碍，但我们未发现血清EPA和AA水平与认知功能之间存在任何显著相关性。
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