多发性硬化症患者嗅觉功能障碍的相关因素
The Factors Associated With Olfactory Dysfunction in Patients with Multiple Sclerosis.
作者信息
Almasi Mostafa, Sahraian Mohammad Ali, Haji Akhoundi Fahimeh, Ezzati Hamid Reza, Rohani Mohammad
机构信息
Department of Neurology, Firouzgar Hospital, Iran University of Medical Sciences, Tehran, Iran.
Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
出版信息
Basic Clin Neurosci. 2021 Jan-Feb;12(1):89-94. doi: 10.32598/bcn.12.1.1368.1. Epub 2021 Jan 1.
INTRODUCTION
An impaired sense of smell has a remarkable impact on the quality of life. It is seen in a variety of neurodegenerative diseases such as Parkinson disease. In this study, we assessed the olfactory function in patients with Multiple Sclerosis (MS) by Sniff Magnitude Test (SMT).
METHODS
A cross-sectional study was conducted on 48 patients with MS. A questionnaire, including demographic and clinical variables, was completed for each patient. The SMT was used for the evaluation of olfactory function.
RESULTS
Olfactory dysfunction was found in 14.6% of patients (8.3% hyposmia and 6.3% anosmia). Older age, longer disease duration, higher hospital admission rate, lower minimental status examination score, and secondary progressive course of MS were significantly related to olfactory dysfunction.
CONCLUSION
Secondary progressive MS and markers of advanced disease toward neurodegenerative phase (including older age, longer disease duration, and lower cognitive function) can be associated with olfactory dysfunction in MS patients.
引言
嗅觉减退对生活质量有显著影响。在帕金森病等多种神经退行性疾病中都可见到。在本研究中，我们通过嗅量测试（SMT）评估了多发性硬化症（MS）患者的嗅觉功能。
方法
对48例MS患者进行了一项横断面研究。为每位患者完成了一份包括人口统计学和临床变量的问卷。使用SMT评估嗅觉功能。
结果
14.6%的患者存在嗅觉功能障碍（嗅觉减退8.3%，嗅觉丧失6.3%）。年龄较大、病程较长、住院率较高、简易精神状态检查评分较低以及MS的继发进展型病程与嗅觉功能障碍显著相关。
结论
继发进展型MS以及疾病向神经退行性阶段发展的晚期标志物（包括年龄较大、病程较长和认知功能较低）可能与MS患者的嗅觉功能障碍有关。
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