Department of Otolaryngology-Head and Neck Surgery, University of Berlin, Charite Campus Mitte, Smell and Taste Consultation Service, Berlin, Germany.
Rhinology. 2011 Jun;49(2):221-6. doi: 10.4193/Rhino10.136.
Some studies reported olfactory dysfunction in patients with multiple sclerosis (MS). There is no agreement about the most suitable testing method for measuring olfactory function (OF) in MS patients. Recent studies showed that olfactory bulb volume changes with the degree of olfactory dysfunction. We assessed olfactory bulb volume of MS patients with magnetic resonance imaging (MRI) and related it to the OF.
Volumetric measurements of the right and left olfactory bulb (OB) were performed by manual segmentation within 36 MS patients. Psychophysical testing of the orthonasal OF was performed using threshold-discrimination-identification (TDI) score in MS patients.
Of all MS patients, 44.4% displayed olfactory dysfunction. The TDI score of all 36 MS patients, especially the score of the Identification subtest correlated strongly with neurological scores typical of MS. In patients with a decreased OB volume, there was a positive correlation between volumetry of the OB and OF.
OB volumes may provide valuable information about MS patients with olfactory dysfunction. The TDI test and Identification subtest were very sensitive in detecting olfactory dysfunction in MS patients.
一些研究报道多发性硬化症（MS）患者存在嗅觉功能障碍。目前对于评估 MS 患者嗅觉功能（OF）最适宜的检测方法尚无共识。近期研究表明，嗅球体积随嗅觉功能障碍程度而变化。我们通过磁共振成像（MRI）评估 MS 患者的嗅球体积，并将其与 OF 相关联。
对 36 例 MS 患者的右侧和左侧嗅球（OB）进行手动分割，以进行体积测量。使用阈值辨别识别（TDI）评分对 MS 患者的鼻内嗅觉功能进行心理物理学测试。
所有 MS 患者中，44.4%存在嗅觉功能障碍。所有 36 例 MS 患者的 TDI 评分，尤其是识别分测验的评分与 MS 患者的典型神经学评分密切相关。在嗅球体积减小的患者中，嗅球体积与 OF 之间呈正相关。
OB 体积可能为存在嗅觉功能障碍的 MS 患者提供有价值的信息。TDI 测试和识别分测验在检测 MS 患者的嗅觉功能障碍方面非常敏感。
