Riis M L
Department of Oncology, Section of Breast- and Endocrine Surgery, Oslo University Hospital, Oslo, Norway.
Ann Med Surg (Lond). 2021 Apr 16;65:102311. doi: 10.1016/j.amsu.2021.102311. eCollection 2021 May.
Germ-line mutation in BRCA (BReast CAncer gene) 1 or BRCA2 are found in 3-4% of all women with breast cancer. These patients have a significant increased risk of breast and ovarian cancer. They are often younger when diagnosed with the mutation, and the possible breast cancer they get is often aggressive with inferior outcome. There are risk reducing strategies, and the most powerful strategy is risk reducing surgery, both risk reducing bilateral mastectomy (RRM) and risk reducing bilateral salpino-oophorectomy (PBSO). This review is meant to address breast surgery in patients with germline BRCA mutation. The guidelines and techniques applied is under continuous change and it is important for the clinicians to be well informed to provide the patient with the information needed for them to make an informed decision on what risk strategy to choose.
在所有乳腺癌女性患者中，3%-4%的人存在BRCA（乳腺癌基因）1或BRCA2的生殖系突变。这些患者患乳腺癌和卵巢癌的风险显著增加。他们在被诊断出携带该突变时往往较为年轻，且患的乳腺癌通常侵袭性强，预后较差。存在降低风险的策略，其中最有效的策略是降低风险的手术，包括降低风险的双侧乳房切除术（RRM）和降低风险的双侧输卵管卵巢切除术（PBSO）。本综述旨在探讨携带生殖系BRCA突变患者的乳房手术。所应用的指南和技术不断变化，临床医生充分了解相关信息很重要，以便为患者提供所需信息，使其能够就是否选择以及选择何种降低风险策略做出明智决定。
