[通过大鼠白细胞减少程度对关节暴露于钚-239和磷酸三丁酯的有效性进行定量评估]
[Quantitative evaluation of the effectiveness of exposure of the joints to 239Pu and tributyl phosphate by the degree of leukopenia in rats].
作者信息
Kalmykova Z I, Chudin V A, Men'shikh Z S
出版信息
Radiobiologiia. 1988 May-Jun;28(3):420-4.
PMID:3399645
Abstract
The efficiency of the combined effect of 239Pu and tributyl phosphate was estimated by the severity of leucopenia in Wistar rats using the regression method and comparing the value of the actual change with the expected one. It was shown that the additive effect of the two agents delivered simultaneously was only exceeded when their doses were the largest that is, approximate the acute levels. With levels ranging from subacute effective to minimum effective ones the additivity diminished.
摘要
通过使用回归方法并比较实际变化值与预期值，根据Wistar大鼠白细胞减少的严重程度评估了239Pu和磷酸三丁酯联合作用的效率。结果表明，只有当两种药剂的剂量最大，即接近急性水平时，同时给药时它们的相加作用才会被超过。在从亚急性有效水平到最小有效水平的范围内，相加性减弱。
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