Pastor Tatiane P, Peixoto Barbara C, Viola João P B
Program of Immunology and Tumor Biology, Brazilian National Cancer Institute (INCA), Rio de Janeiro, Brazil.
Front Cell Dev Biol. 2021 Apr 29;9:655307. doi: 10.3389/fcell.2021.655307. eCollection 2021.
Interferon regulatory factor 2-binding protein 2 (IRF2BP2) encodes a member of the IRF2BP family of transcriptional regulators, which includes IRF2BP1, IRF2BP2, and IRF2BPL (EAP1). IRF2BP2 was initially identified as a transcriptional corepressor that was dependent on Interferon regulatory factor-2 (IRF-2). The IRF2BP2 protein is found in different organisms and has been described as ubiquitously expressed in normal and tumor cells and tissues, indicating a possible role for this transcriptional cofactor in different cell signaling pathways. Recent data suggest the involvement of IRF2BP2 in the regulation of several cellular functions, such as the cell cycle, cell death, angiogenesis, inflammation and immune response, thereby contributing to physiological cell homeostasis. However, an imbalance in IRF2BP2 function may be related to the pathophysiology of cancer. Some studies have shown the association of IRF2BP2 expression in hematopoietic and solid tumors through mechanisms based on gene fusion and point mutations in gene coding sequences, and although the biological functions of these types of hybrid and mutant proteins are not yet known, they are thought to be involved in an increase in the likelihood of tumor development. In this review, we address the possible involvement of IRF2BP2 in tumorigenesis through its regulation of important pathways involved in tumor development.
干扰素调节因子2结合蛋白2（IRF2BP2）编码转录调节因子IRF2BP家族的一个成员，该家族包括IRF2BP1、IRF2BP2和IRF2BPL（EAP1）。IRF2BP2最初被鉴定为一种依赖于干扰素调节因子2（IRF-2）的转录共抑制因子。IRF2BP2蛋白存在于不同的生物体中，据描述在正常细胞和肿瘤细胞及组织中普遍表达，这表明该转录辅因子在不同细胞信号通路中可能发挥作用。最近的数据表明IRF2BP2参与多种细胞功能的调节，如细胞周期、细胞死亡、血管生成、炎症和免疫反应，从而有助于维持细胞生理稳态。然而，IRF2BP2功能的失衡可能与癌症的病理生理学有关。一些研究通过基于基因融合和基因编码序列点突变的机制，表明了IRF2BP2在造血肿瘤和实体瘤中的表达关联，尽管这些类型的杂交和突变蛋白的生物学功能尚不清楚，但它们被认为与肿瘤发生可能性的增加有关。在本综述中，我们探讨了IRF2BP2通过调节肿瘤发展相关重要通路可能参与肿瘤发生的情况。
