Chen LinLin, Wu Jiao, Hu Bin, Liu Changbai, Wang Hu
Affiliated Ren He Hospital of China Three Gorges University, Yichang 443002, China.
Medical School, China Three Gorges University, 8 Daxue Road, Yichang 443002, China.
Biomed Res Int. 2021 Apr 28;2021:6651075. doi: 10.1155/2021/6651075. eCollection 2021.
The common kidney disease diabetic nephropathy (DN) accounts for significant morbidity and mortality in patients with diabetes, and its effective diagnosis in incipient stages is still lacking. Renal fibrosis is the main pathological feature of DN. Cell division autoantigen 1 (CDA1), a phosphorylated protein encoded by TSPYL2 on the X chromosome, plays a fibrogenic role by modulating the transforming growth factor- (TGF-) signaling, but the exact mechanism remains unclear. TGF- signaling has been recognized as the key factor in promoting the development and progression of DN. At present, strict control of blood sugar and blood pressure can significantly lower the development and progression of DN in the early stages, and many studies have shown that blocking TGF- signaling can delay the progress of DN. However, TGF- is a multifunctional cytokine. Its direct intervention may result in increased side effects. Therefore, the targeted intervention of CDA1 not only can block the TGF- signaling pathway but also can reduce these side effects. In this article, we review the main physiological roles of CDA1, with particular attention to its effect and potential mechanism in the renal fibrosis of DN.
常见的肾脏疾病糖尿病肾病（DN）在糖尿病患者中导致了显著的发病率和死亡率，并且在其早期阶段仍缺乏有效的诊断方法。肾纤维化是DN的主要病理特征。细胞分裂自身抗原1（CDA1）是一种由X染色体上的TSPYL2编码的磷酸化蛋白，它通过调节转化生长因子-β（TGF-β）信号传导发挥促纤维化作用，但其确切机制仍不清楚。TGF-β信号传导已被认为是促进DN发生和发展的关键因素。目前，严格控制血糖和血压可显著降低DN在早期阶段的发生和发展，并且许多研究表明阻断TGF-β信号传导可延缓DN的进展。然而，TGF-β是一种多功能细胞因子。其直接干预可能会导致副作用增加。因此，对CDA1进行靶向干预不仅可以阻断TGF-β信号通路，还可以减少这些副作用。在本文中，我们综述了CDA1的主要生理作用，特别关注其在DN肾纤维化中的作用及潜在机制。
