Wang Dan, Chen Fengjiao, Zeng Tao, Tang Qingxia, Chen Bing, Chen Ling, Dong Yan, Li Xiaosong
Department of Clinical Laboratory, People's Hospital of Rongchang District, Chongqing, Rongchang 402460, PR China.
Key Laboratory of Molecular Biology of Infectious Diseases, Ministry of Education, Chongqing Medical University, Chongqing, 400016, PR China.
Genes Dis. 2020 Jan 8;8(2):157-167. doi: 10.1016/j.gendis.2019.12.013. eCollection 2021 Mar.
Thousands of long non-coding RNAs (lncRNAs) have been discovered in human genomes by gene chip, next-generation sequencing, and/or other methods in recent years, which represent a significant subset of the universal genes involved in a wide range of biological functions. An abnormal expression of lncRNAs is associated with the growth, invasion, and metastasis of various types of human cancers, including hepatocellular carcinoma (HCC), which is an aggressive, highly malignant, and invasive tumor, and a poor prognosis in China. With a more in-depth understanding of lncRNA research for HCC and the emergence of new molecular-targeted therapies, the diagnosis, treatment, and prognosis of HCC will be considerably improved. Therefore, this review is expected to provide recommendations and directions for future lncRNA research for HCC.
近年来，通过基因芯片、新一代测序和/或其他方法，在人类基因组中发现了数千种长链非编码RNA（lncRNA），它们是参与广泛生物学功能的普遍基因的重要子集。lncRNA的异常表达与包括肝细胞癌（HCC）在内的各种人类癌症的生长、侵袭和转移相关，HCC是一种侵袭性强、高度恶性且具有侵袭性的肿瘤，在中国预后较差。随着对HCC的lncRNA研究的更深入了解以及新的分子靶向治疗方法的出现，HCC的诊断、治疗和预后将得到显著改善。因此，本综述有望为未来HCC的lncRNA研究提供建议和方向。
