Walsh J K, Sugerman J L, Muehlbach M J, Schweitzer P K
Deaconess Hospital Sleep Disorders Center, St. Louis, Missouri 63139.
Sleep. 1988 Jun;11(3):251-64. doi: 10.1093/sleep/11.3.251.
Daytime sleep and nocturnal sleepiness were examined in 18 normal sleepers (9 young adults, 9 middle-age adults) for 5.5 days following acute sleep/wake schedule inversion. Triazolam and placebo were compared in a counterbalanced, crossover design. Triazolam improved daytime sleep, but did not produce significant changes in sleep tendency at night. Physiological sleep tendency in the early morning hours (0200 to 0600) was profound, but decreased significantly within 3 to 4 days following sleep/wake inversion, irrespective of treatment condition. Nocturnal performance data generally were consistent with changes in physiological sleep tendency. We conclude that extending daytime sleep by an average of approximately 50 min per day via administration of a hypnotic does not appear to significantly reduce circadian sleep tendency in the early morning hours. Further, considerable adaptation, in terms of sleep tendency, occurred within a weak of simulated night shift despite a relatively constant daytime sleep pattern.
在18名正常睡眠者（9名年轻人，9名中年人）中，对急性睡眠/觉醒时间表颠倒后的5.5天内的日间睡眠和夜间嗜睡情况进行了检查。采用平衡交叉设计比较了三唑仑和安慰剂。三唑仑改善了日间睡眠，但夜间睡眠倾向没有显著变化。清晨时段（02:00至06:00）的生理睡眠倾向很强，但在睡眠/觉醒颠倒后的3至4天内显著下降，与治疗条件无关。夜间表现数据总体上与生理睡眠倾向的变化一致。我们得出结论，通过服用催眠药使日间睡眠平均每天延长约50分钟，似乎并不能显著降低清晨时段的昼夜睡眠倾向。此外，尽管白天睡眠模式相对恒定，但在模拟夜班的一周内，睡眠倾向发生了相当大的适应性变化。
