Leicester Institute of Structural and Chemical Biology and School of Chemistry, University of Leicester, Henry Wellcome Building, Lancaster Road, Leicester, LE1 7RH, UK.
Department of Molecular and Cell Biology, University of Leicester, Henry Wellcome Building, Lancaster Road, Leicester, LE1 7RH, UK.
Chem Commun (Camb). 2021 Jun 10;57(47):5778-5781. doi: 10.1039/d1cc01425k.
Tetrahydrofolic acid and formaldehyde are key human metabolites but their physiologically relevant chemistry is undefined. Our NMR studies confirm formaldehyde as a product of tetrahydrofolic acid degradation but also reveal their reaction regulates the stability of tetrahydrofolic acid. These observations identify a novel non-enzymatic feedback mechanism regulating formaldehyde and folate metabolism that has important implications for folate-targeting chemotherapy in cancer and other diseases.
四氢叶酸和甲醛是关键的人体代谢物，但它们在生理相关条件下的化学反应尚未明确。我们的 NMR 研究证实了甲醛是四氢叶酸降解的产物，但也揭示了它们的反应调节了四氢叶酸的稳定性。这些观察结果确定了一种新的非酶反馈机制，调节甲醛和叶酸代谢，这对癌症和其他疾病中针对叶酸的化疗具有重要意义。
