Department of Neurology, Buffalo Neuroimaging Analysis Center, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, 100 High St., Buffalo, NY, 14203, USA.
Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, Jacobs Comprehensive MS Treatment and Research Center, University at Buffalo, Buffalo, NY, USA.
J Neurol. 2021 Dec;268(12):4796-4808. doi: 10.1007/s00415-021-10594-7. Epub 2021 May 16.
The nucleus basalis of Meynert (NBM), representing the major source of cerebral cholinergic innervations, is vulnerable to neurodegeneration in Alzheimer's and Parkinson's disease.
To determine associations between NBM properties and cognitive outcomes in patients with multiple sclerosis (PwMS).
84 PwMS and 19 controls underwent 3T MRI, the Paced Auditory Serial Addition Test (PASAT) and subtests of the Brief International Cognitive Assessment for MS (BICAMS). NBM volume, fractional anisotropy, mean diffusivity (MD), axial diffusivity and radial diffusivity (D) were calculated. Analyses assessed relationships between cognition and NBM measures. Linear regressions evaluated the prognostic value of baseline measures in predicting cognitive change over 3 years of follow-up (n = 67).
Cognitive tests correlated with NBM diffusivity in PwMS (range r = - 0.29 to r = - 0.40, p < 0.05). After accounting for NBM volume, NBM MD and D explained additional variance (adjusted R range 0.08-0.20, p < 0.05). Correlations between NBM imaging metrics and cognitive tests remained significant when including imaging parameters of other cognitive key brain regions in the models. After controlling for age, education, and baseline cognitive test score, NBM measures predicted change in cognition over follow-up in 5 of 10 and 2 of 10 assessments in the relapsing-remitting sample (n = 43) (adjusted R range from 0.23 to 0.38, p < 0.05) and secondary progressive sample (adjusted R of 0.280 and 0.183), respectively.
NBM damage is linked to cognitive impairment in PwMS.
基底核梅内尔特核（NBM）是大脑胆碱能神经支配的主要来源，易发生阿尔茨海默病和帕金森病的神经退行性变。
确定多发性硬化症（PwMS）患者的 NBM 特性与认知结果之间的相关性。
84 名 PwMS 和 19 名对照接受了 3T MRI、听觉连续加法测试（PASAT）和多发性硬化症简明国际认知评估测试（BICAMS）的子测试。计算了 NBM 体积、各向异性分数、平均扩散系数（MD）、轴向扩散系数和径向扩散系数（D）。分析评估了认知与 NBM 测量值之间的关系。线性回归评估了基线测量值在预测 3 年随访期间认知变化的预后价值（n=67）。
认知测试与 PwMS 的 NBM 扩散性相关（范围 r=-0.29 至 r=-0.40，p<0.05）。在考虑 NBM 体积后，NBM MD 和 D 解释了额外的方差（调整后的 R 范围为 0.08-0.20，p<0.05）。当将其他认知关键脑区的影像学参数纳入模型时，NBM 影像学指标与认知测试之间的相关性仍然显著。在控制年龄、教育程度和基线认知测试评分后，NBM 测量值在复发缓解样本（n=43）中预测了随访期间认知变化的 5/10 和 2/10 评估（调整后的 R 范围为 0.23 至 0.38，p<0.05），在继发性进展样本中分别为 0.280 和 0.183（调整后的 R）。
NBM 损伤与 PwMS 的认知障碍有关。
