Nair Sanjita, Nisha K J
Department of Periodontics, Vydehi Institute of Dental Sciences and Research Center, Bengaluru, India.
J Periodontol. 2022 Feb;93(2):177-186. doi: 10.1002/JPER.21-0179. Epub 2021 May 27.
Fetuin-A has garnered recognition in the etiopathogenesis of several systemic disorders. It has been recently acknowledged as an anti-inflammatory marker for periodontal disease. This study aimed to compare and correlate salivary and serum fetuin-A levels in health and patients with stages II-III periodontitis along with evaluating the effect of non-surgical periodontal therapy (NSPT) on the same.
Group 1 comprised of 30 healthy subjects. Group 2 embodied 30 patients with stages II-III periodontitis. Clinical periodontal parameters were recorded. Saliva and serum samples were assembled. Periodontitis patients received non-surgical periodontal treatment. They were recalled after 6 months, and collection of samples and recording of clinical parameters were reiterated. Fetuin-A levels were analyzed using ELISA.
Salivary and serum fetuin-A levels were significantly lower in periodontitis patients when compared with the healthy subjects (P < 0.001) at baseline. Their concentrations significantly upregulated 6 months after active periodontal therapy (P < 0.001). Salivary fetuin-A levels revealed a significant positive correlation with their serum levels in Group 1 at baseline (P < 0.001). They also displayed a positive correlation in Group 2 at baseline and 6 months post periodontal therapy, nevertheless failed to establish a statistically significant association.
CONCLUSION(S): Our study concluded that salivary and serum fetuin-A levels diminished with increasing severity of periodontal inflammation, and NSPT remarkably improved their levels. They also displayed a significant positive correlation in health, and a non-significant, yet positive correlation in patients with periodontitis.
胎球蛋白-A在多种全身性疾病的发病机制中已受到关注。最近它被公认为牙周疾病的一种抗炎标志物。本研究旨在比较和关联健康者与II-III期牙周炎患者唾液和血清中的胎球蛋白-A水平，并评估非手术牙周治疗（NSPT）对其的影响。
第1组由30名健康受试者组成。第2组包含30名II-III期牙周炎患者。记录临床牙周参数。收集唾液和血清样本。牙周炎患者接受非手术牙周治疗。6个月后对他们进行回访，再次收集样本并记录临床参数。使用酶联免疫吸附测定法（ELISA）分析胎球蛋白-A水平。
在基线时，与健康受试者相比，牙周炎患者唾液和血清中的胎球蛋白-A水平显著降低（P < 0.001）。积极牙周治疗6个月后，它们的浓度显著上调（P < 0.001）。在第1组基线时，唾液胎球蛋白-A水平与其血清水平呈显著正相关（P < 0.001）。在第2组基线时以及牙周治疗后6个月，它们也显示出正相关，但未建立统计学上的显著关联。
我们的研究得出结论，唾液和血清胎球蛋白-A水平随牙周炎症严重程度的增加而降低，非手术牙周治疗显著提高了它们的水平。它们在健康者中显示出显著正相关，在牙周炎患者中显示出非显著但为正的相关性。
