Department of Pharmaceutical Toxicology, Faculty of Pharmacy, 37520İnönü University, Malatya, Turkey.
Department of Thoracic Surgery, Faculty of Medicine, 37507Dicle University, Diyarbakır, Turkey.
Hum Exp Toxicol. 2021 Nov;40(11):1817-1824. doi: 10.1177/09603271211017324. Epub 2021 May 17.
Malignant pleural mesothelioma (MPM) is a malignant tumor that is associated mostly with asbestos exposure. The present study was to evaluates the diagnostic value of neopterin, periostin, YKL-40, Tenascin-C (TNC), and Indolamine 2,3-dioxygenase (IDO) as noninvasive markers of malign pleural mesothelioma.
Included in the study were 30 patients diagnosed with malign pleural mesothelioma, and 25 people as a control group. Biomarker levels were determined using an enzyme immunoassay . A Mann-Whitney U test and Spearman correlation methods were used for the statistical analysis.
All evaluated biomarkers were found to be significantly higher in the MPM group than in the control group ( < 0.05). There was no effect of such variables as gender, age or MPMsubtype on the parameters ( > 0.05) in the patient group. All biomarkers were positively correlated with each other ( < 0.001).
The current non-invasive biomarkers that can be used in the diagnosis of MPM yielded significant results and can make important contributions to the early diagnosis of MPM.
恶性胸膜间皮瘤（MPM）是一种与石棉暴露密切相关的恶性肿瘤。本研究旨在评估新型喋呤、骨膜蛋白、YKL-40、Tenascin-C（TNC）和吲哚胺 2,3-双加氧酶（IDO）作为恶性胸膜间皮瘤无创性标志物的诊断价值。
本研究纳入了 30 名被诊断为恶性胸膜间皮瘤的患者和 25 名对照组。采用酶联免疫吸附法测定生物标志物水平。采用曼-惠特尼 U 检验和斯皮尔曼相关性分析方法进行统计学分析。
所有评估的生物标志物在 MPM 组中均明显高于对照组（<0.05）。在患者组中，性别、年龄或 MPM 亚型等变量对参数没有影响（>0.05）。所有生物标志物之间均呈正相关（<0.001）。
目前用于 MPM 诊断的非侵入性生物标志物取得了显著结果，可为 MPM 的早期诊断做出重要贡献。
