Anniko M
Department of Oto-Rhino-Laryngology, Head & Neck Surgery, Umea University Hospital, Sweden.
Scanning Microsc. 1988 Jun;2(2):1035-41.
Specimens from the organ of Corti were taken from regions which appeared normal in the cytocochleogram as evaluated with the Nomarski optics. Ultrastructural, qualitative analyses of aging cochlear hair cells in the guinea pig showed, however, principally five distinct types of pathological changes: (1) disintegration of the cuticle; (2) increased amounts of intracellular lamellar structures and submembrane cisternae; (3) aggregations of electron optically dense particles; (4) lysosome-like structures; and (5) vesiculation of cytoplasm. Stereocilia remained intact also in cells where the cuticular plate showed severe degeneration. Outer hair cells showed more extensive cytological changes than inner hair cells. The ultrastructural pathology in aging cochlear hair cells is specific and is a sign of dysdifferentiation of their specific morphology although the hair cells survive for a long time in a more or less dysdifferentiated state. Hair cell changes were primary, leaving afferent and efferent nerve terminals initially morphologically intact.
从柯蒂氏器获取的标本取自用诺马斯基光学显微镜评估时细胞耳蜗电图显示正常的区域。然而，对豚鼠老化耳蜗毛细胞的超微结构定性分析主要显示出五种不同类型的病理变化：（1）表皮层解体；（2）细胞内板层结构和膜下池数量增加；（3）电子致密颗粒聚集；（4）溶酶体样结构；（5）细胞质空泡化。在表皮板显示严重退化的细胞中，静纤毛也保持完整。外毛细胞比内毛细胞表现出更广泛的细胞学变化。老化耳蜗毛细胞的超微结构病理学是特异性的，是其特定形态分化异常的标志，尽管毛细胞在或多或少分化异常的状态下存活很长时间。毛细胞变化是原发性的，传入和传出神经末梢最初在形态上保持完整。
