Department of Mining-Metallurgy Engineering and Materials Science, POLYMAT, University of The Basque Country (UPV/EHU), School of Engineering I, Plaza Ingeniero Torres Quevedo 1, Bilbao, Spain.
J Mater Chem B. 2021 May 26;9(20):4219-4229. doi: 10.1039/d0tb02964e.
This paper reports the obtention of amorphous solid dispersions (ASDs) of xanthohumol (XH) in PCL containing up to 50 wt% of the bioactive compound in the amorphous form thanks to the advantageous specific interactions established in this system. The miscibility of the PCL/XH blends was investigated using DSC. Melting point depression analysis yielded a negative interaction parameter indicating the occurrence of favorable inter-association interactions. XRD analyses performed at room temperature agree with the crystallinity results obtained on the heating runs performed by DSC. FTIR spectroscopy reveals strong C[double bond, length as m-dash]OO-H specific interactions between the hydroxyl groups of XH and the carbonyl groups of PCL. The AFM analysis of the blends obtained by spin-coating shows the variation of crystalline morphology with composition. Finally, tensile tests reveal high toughness retention for the blends in which XH can be dispersed in the amorphous form (containing up to 50 wt% XH). In summary, PCL is a convenient matrix to disperse XH in the amorphous form, bringing the possibility of obtaining completely amorphous bioactive materials suitable for the development of non-stiff biomedical devices.
本文报道了通过在聚己内酯（PCL）中获得高达 50wt%的生物活性化合物的无定形形式，从而获得姜黄素（XH）的无定形固体分散体（ASD），这得益于该体系中建立的有利的特定相互作用。使用 DSC 研究了 PCL/XH 共混物的混溶性。熔点降低分析得出了负相互作用参数，表明发生了有利的相互缔合相互作用。在室温下进行的 XRD 分析与 DSC 进行的加热运行获得的结晶度结果一致。傅立叶变换红外光谱（FTIR）揭示了 XH 的羟基和 PCL 的羰基之间存在强的 C[双键，长度为破折号]OO-H 特定相互作用。通过旋涂获得的共混物的 AFM 分析表明，结晶形态随组成而变化。最后，拉伸试验表明，在 XH 可以分散在无定形形式（含高达 50wt%XH）的共混物中保持高韧性。总之，PCL 是一种方便的基质，可以将 XH 分散在无定形形式中，从而有可能获得完全无定形的生物活性材料，适用于非刚性生物医学装置的开发。
