The purpose of this review is to systematically assess the existing literature and summarize the evidence regarding the effect of erbium-doped yttrium aluminum garnet (Er:YAG) laser on enamel surface roughness and pulp health compared with the conventional orthodontic debonding techniques. Following the preferred reporting items for systematic reviews (Preferred Reporting Items for Systematic Reviews and Meta-analyses) statement, the electronic database, PubMed, Scopus, Web of Science, Google scholar, and Saudi Digital Library were searched for relevant published records. Data were collected following specific keywords: "debonding" "Er:YAG laser" etc. studies, and clinical randomized- and nonrandomized-controlled studies limited to the English language and published in peer-reviewed journals were included. A total of 564 articles were identified as relevant to the topic. Duplicates were excluded resulting in 382 articles, out of which 374 articles were discarded upon screening titles and abstracts. The remaining eight articles were read to their entirety and included in the current qualitative review after fulfilling the eligibility criteria. In all the included studies, a total of 480 sound posterior teeth were used to evaluate the effect of Er:YAG laser on debonding of orthodontic brackets from the enamel surface. Er:YAG laser debonding has demonstrated a reduced risk of enamel damage (fracture or cracks) but resulted in increased enamel surface roughness and was time-consuming for adhesive removal procedures compared with the conventional debonding methods. Further, within the applied laser settings, Er:YAG lasers have found to exhibit low thermal exhaustion in relation to the pulp. The laser source with a wavelength of 2940 nm has been used with different setting ranges (power of 2.5-5 W, energy 125-600 mJ, frequency 4-30 Hz, and pulse duration 50-350 μsec) for debonding of orthodontic brackets.