Neuman Daniel L, Chadwick Andrea L
From the Department of Anesthesiology, University of Kansas Medical Center, Kansas City, Kansas.
A A Pract. 2021 May 17;15(5):e01475. doi: 10.1213/XAA.0000000000001475.
Burning mouth syndrome is a chronic pain condition characterized by a burning sensation of the oropharynx. The pathophysiology of burning mouth syndrome includes peripheral and central sensitization. Treatment is generally aimed at symptom reduction. We describe a woman in her seventh decade with burning mouth syndrome that had been refractory to treatment for nearly a decade. Low-dose naltrexone has been reported to provide analgesia in central sensitization states and was successful in reducing pain severity in our patient. We conclude that low-dose naltrexone may be a therapeutic option for patients with burning mouth syndrome who are refractory to conventional therapies.
灼口综合征是一种以口咽烧灼感为特征的慢性疼痛病症。灼口综合征的病理生理学包括外周和中枢敏化。治疗通常旨在减轻症状。我们描述了一位七十多岁患有灼口综合征的女性，该病症近十年来一直对治疗无效。据报道，低剂量纳曲酮可在中枢敏化状态下提供镇痛作用，并且在我们的患者中成功减轻了疼痛严重程度。我们得出结论，对于对传统疗法无效的灼口综合征患者，低剂量纳曲酮可能是一种治疗选择。
