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低剂量纳曲酮在慢性疼痛中的应用。

The Utilization of Low Dose Naltrexone for Chronic Pain.

机构信息

Department of Anesthesiology, Mount Sinai Medical Center, 4300 Alton Road, Miami Beach, FL, USA.

Creighton University School of Medicine Phoenix, Phoenix, AZ, USA.

出版信息

CNS Drugs. 2023 Aug;37(8):663-670. doi: 10.1007/s40263-023-01018-3. Epub 2023 Jul 28.

Abstract

Naltrexone is a mu-opioid receptor antagonist with a long half-life compared with naloxone. Both of these drugs, along with others, were developed with the intention of reversing the effects of opioid abuse or toxicity. Evidence has also shown that naltrexone has a benefit in preventing relapse by reducing opioid cravings and reducing symptoms of opioid withdrawal. The benefits of this drug were not only shown with opioid abuse. In 1984 this drug was also approved for alcohol abuse. Naltrexone has been proven to decrease alcohol relapse by decreasing the craving. Apart from these approved indications for the use of naltrexone, with time, it has been seen that this drug has a benefit in treating chronic pain. A number of studies have shown the benefits of this drug with inflammatory bowel disease, fibromyalgia, multiple sclerosis, diabetic neuropathy, and complex regional pain syndrome, among others. More studies are needed to approve this medication for specific chronic pain conditions.

摘要

纳曲酮是一种与纳洛酮相比半衰期较长的μ-阿片受体拮抗剂。这些药物以及其他一些药物的开发目的是逆转阿片类药物滥用或中毒的影响。有证据表明,纳曲酮通过减少阿片类药物的渴望和减少阿片类药物戒断症状,在预防复发方面具有益处。这种药物的益处不仅在阿片类药物滥用方面得到了证明。1984 年,这种药物也被批准用于治疗酒精滥用。纳曲酮已被证明可通过减少渴望来减少酒精复发。除了这些已批准的纳曲酮使用适应症外,随着时间的推移,人们发现这种药物在治疗慢性疼痛方面具有益处。多项研究表明,这种药物对炎症性肠病、纤维肌痛、多发性硬化症、糖尿病性神经病和复杂性区域疼痛综合征等疾病具有益处。需要更多的研究来批准这种药物用于治疗特定的慢性疼痛疾病。

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